iSharesSectorsHealth Care#2 of 264 by YTD

iShares Genomics Immunology and Healthcare ETFIDNA

S&P 500 Bucket avg Compare

$43.57+3.0%

+$1.26 · Nov 9 close

Buy

AUM: $346M
Fee: 0.47%
Yield: 0.6%

Bumpy · 1Y: 2.3×S&P
Volume: 252K
NAV: $42.24

What's insideAll 62 →

MRNA 14.9%GMAB.CO 5.9%TWST 4.9%BAYN.DE 4.1%

52-week range1% below the high

$24.29$44.15

Returns	Today	1W	1M	3M	YTD	1Y	3Y	5Y	Max
Total return	+3.0%	+4.5%	+3.3%	+23.8%	+67.1%	+76.1%	+142.3%	−9.5%	+88.0%
Peer average	+2.4%	+2.8%	+6.4%	+5.5%	+23.4%	+33.1%	+76.7%	+28.9%	—
S&P 500 · VOO	+2.3%	+0.1%	−3.3%	−2.1%	+11.3%	+13.6%	+81.6%	+75.4%	—

IDNA in One Breath

IDNA Among Health Care ETFs

YTD

#1IDNAiShares+67.1%$346M

#2ARKGARK+66.6%$2.2B

#3XHSSPDR+37.5%$241M

#4BBHVanEck+37.1%$524M

#5FTXHFirst Trust+35.3%$1.2B

#6BBPVirtus+30.8%$131M

#7PSCHInvesco+29.7%$181M

#8XBISPDR+28.8%$10.3B

#9IHEiShares+26.8%$1.7B

End-of-day Nov 9, 2026 · 33 Health care ETFs by YTD

$10,000 in IDNA

$10,000 in IDNA became

$9,047

In the S&P 500 (VOO)

$17,543

Total return, dividends in · Nov 1, 2021 – Nov 9, 2026 · S&P 500 uses VOO

IDNA’s Top Holdings

Today

MRNAModerna14.9%GMAB.CO5.9%TWST4.9%BAYN.DE4.1%REGN4.0%4502.T3.7%EXEL3.7%RVMD3.6%VRTX3.4%MRK3.4%INCY3.3%ROP.SW3.2%SAN.PA2.9%IBRX2.8%BNTX2.8%IOVA2.7%GSK.L2.7%IPN.PA2.7%CAI2.7%ABCL2.4%IDYA2.3%28 more

MRNAModerna14.9%GMAB.CO5.9%TWST4.9%BAYN.DE4.1%REGN4.0%4502.T3.7%EXEL3.7%RVMD3.6%VRTX3.4%MRK3.4%INCY3.3%38 more

BiotechnologyDrug Manufacturers - GeneralDrug Manufacturers - Specialty

iShares IDNA · 50 holdings · tile size = share of the fund · as of Nov 9, 2026

What IDNA Holds

Today

Biotechnology71.1%

MRNA 14.9 · GMAB.CO 5.9 · TWST 4.9 · REGN 4.0 · EXEL 3.7 · RVMD 3.6 · VRTX 3.4

Drug Manufacturers - General17.8%

BAYN.DE 4.1 · MRK 3.4 · ROP.SW 3.2 · SAN.PA 2.9 · GSK.L 2.7 · 4528.T 1.5

Drug Manufacturers - Specialty & Generic7.6%

4502.T 3.7 · IPN.PA 2.7 · 6887.HK · ALVO

Medical - Diagnostics & Research0.9%

PSNL

Medical - Devices0.6%

PACB

Other holdings2.0%

VLA.PA · 2696.HK · DSGN · CTMX · OCGN · 174900.KQ

iShares IDNA · share of the fund by industry · as of Nov 9, 2026

Moderna’s Share of IDNA

Today

14.9%

$149 of every $1,000 in IDNA is Moderna

Moderna held by IDNA

$51.7M

Most Moderna per dollar

IDNA14.9%

GNOM13.6%

GNMX11.6%

BBH7.7%

iShares IDNA · each square = $10 of $1,000 · as of Nov 9, 2026

IDNA’s Share of Health Care ETFs

Today

0.3%

of the $110B in 39 Health care ETFs

IDNA$346M0.3%

XLV$49.7B45.1%

VHT$19.1B17.3%

36 others$41.0B37.2%

Health care ETF AUM · Nov 9, 2026

IDNA Fee per $100 vs Peers

Today

$0.47a year
per $100

$47 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

IDNA$0.47

Expense ratio · Health care peers · Nov 9, 2026

Inside IDNA

50 holdings · as of Nov 9, 2026

IDNA

iShares Genomics Immunology and Healthcare ETF

Today

Biotechnology71.1%MRNAModerna14.9%GMAB.CO5.9%TWST4.9%REGN4.0%EXEL3.7%RVMD3.6%VRTX3.4%INCY3.3%IBRX2.8%BNTX2.8%IOVA2.7%CAI2.7%ABCL2.4%IDYA15 more holdings11.8% of the fundDrug Manufacturers - General17.8%BAYN.DE4.1%MRK3.4%ROP.SW3.2%SAN.PAGSK.L2.7%Drug Manufacturers - Specialty7.6%4502.T3.7%IPN.PA2.7%ALVOPSNLOther2.0%

Biotechnology71.1%MRNA14.9%GMAB.CO5.9%TWST4.9%REGN4.0%EXEL3.7%23 more holdings34.2% of the fundDrug Manufacturers - General17.8%BAYN.DMRKROP.SWSAN.PAGSK.LDrug Manufacturers - Specialty7.6%IPN.PAALVOPSNLPACB

#	Ticker	Company	Weight ▼
1	MRNA	Moderna	14.92%
2	GMAB.CO	Genmab	5.94%
3	TWST	Twist Bioscience	4.86%
4	BAYN.DE	Bayer AG	4.13%
5	REGN	Regeneron Pharmaceuticals	3.96%
6	4502.T	Takeda Pharmaceutical	3.75%
7	EXEL	Exelixis	3.67%
8	RVMD	Revolution Medicines	3.59%
9	VRTX	Vertex Pharmaceuticals	3.41%
10	MRK	Merck &	3.38%

See all 62 holdings ↓

BiotechnologyDrug Manufacturers - GeneralDrug Manufacturers - SpecialtyMedical - DiagnosticsMedical - DevicesOther

iShares IDNA · current holdings by weight · as of Nov 9, 2026 · each tile is one holding · top 20 = 79.8%

All IDNA Holdings

62 holdings · as of Nov 9, 2026

IDNA

IDNA’s Holdings

Today

#
1	MRNAModerna	Healthcare	14.92%	$1,491.54	206K	$52.5M
2	GMAB.COGenmab	Healthcare	5.94%	$594.11	40K	$20.9M
3	TWSTTwist Bioscience	Healthcare	4.86%	$485.75	142K	$17.1M
4	BAYN.DEBayer AG	Healthcare	4.13%	$412.85	234K	$14.5M
5	REGNRegeneron Pharmaceuticals	Healthcare	3.96%	$396.12	15K	$13.9M
6	4502.TTakeda Pharmaceutical	Healthcare	3.75%	$374.86	318K	$13.2M
7	EXELExelixis	Healthcare	3.67%	$367.29	186K	$12.9M
8	RVMDRevolution Medicines	Healthcare	3.59%	$358.70	66K	$12.6M
9	VRTXVertex Pharmaceuticals	Healthcare	3.41%	$340.90	22K	$12.0M
10	MRKMerck	Healthcare	3.38%	$338.28	81K	$11.9M
11	INCYIncyte	Healthcare	3.25%	$325.08	96K	$11.4M
12	ROP.SWRoche PS PAR AG	Healthcare	3.22%	$321.62	24K	$11.3M
13	SAN.PASanofi	Healthcare	2.89%	$288.63	109K	$10.2M
14	IBRXImmunitybio	Healthcare	2.84%	$283.82	1.2M	$10.0M
15	BNTXBiontech SE	Healthcare	2.77%	$276.74	111K	$9.7M

iShares IDNA · every reported holding · per $10,000 = dollars of each holding in a $10,000 stake · as of Nov 9, 2026

How It Compares

IDNA

iShares Genomics Immunology and Healthcare ETF’s Peers

YTD


XLV	SPDRRead Desk	0.08%	+23.2%	+31.2%	$49.7B
VHT	VanguardRead Desk	0.09%	+22.2%	+29.9%	$19.1B
XBI	SPDRRead Desk	0.35%	+28.8%	+44.2%	$10.3B
IYH	iSharesRead Desk	0.37%	+22.4%	+30.4%	$4.7B
IXJ	iSharesRead Desk	0.38%	+19.1%	+27.0%	$4.6B
IDNA	iSharesThis fundRead Desk	0.47%	+67.1%	+76.1%	$346M

Health care peers · YTD and past-year returns · as of Nov 10, 2026 · sorted by AUM

Head to Head

Put IDNA head to head with XLV →

XLV vs IDNA

YTD

XLVSPDR · Health careIDNAiShares · Health care

Year to date

+23.2%

+67.1%

IDNA wins+43.9 pts

Past year

+31.2%

+76.1%

IDNA wins+44.9 pts

Fee

0.08%

0.47%

XLV winslower fee

Yield

1.4%

0.6%

XLV wins+0.7 pts

AUM

$49.7B

$346M

XLV143.5× more

2–2level

SPDR XLV and iShares IDNA · year-to-date · as of Nov 10, 2026 · AUM not scored

IDNA vs VOO

YTD

IDNA · iShares Genomics Immunology and Healthcare

+67.1%

VOO · S&P 500

+11.3%

Gap

55.8 pts

iShares IDNA and Vanguard VOO · YTD total return · as of Nov 10, 2026

IDNA vs Its Peer Average

YTD

IDNAAvsBPeer average

1D+3.0%+2.4%

1M+3.3%+6.4%

3M+23.8%+5.5%

YTD+67.1%+23.4%

1Y+76.1%+33.1%

3Y+142.3%+76.7%

5Y−9.5%+28.9%

5–2IDNA wins

38 Health care peers · each row scaled to its leader

How Bumpy Is IDNA?

View

IDNA

How Bumpy

2.3×the S&P 500’s swings

CalmerBumpierS&P 1×IDNA

Bumpiest of 7 health care fundsIDNA

Other health care funds1.2× to 2.2×

iShares IDNA · daily swings over the past year vs the S&P 500

IDNA

Worst Drop

−10.6%from its Feb 27 high

Still below the high−1.3%

$10,000 at the high is now$9,870

iShares IDNA · fall from the highest close, past year

IDNA

On a Bad Day

0.8×the S&P 500’s fall

IDNA’s worst day: Thursday, Nov 5

IDNA

−6.2%

S&P 500

−4.4%

Up days55 of every 100

S&P 500 up days52 of every 100

iShares IDNA · average move on days the S&P 500 fell

IDNA

Return for the Bumps

1Y#1 of 7 health care funds

#1IDNAiShares

most for the bumps

#2XLVSPDR

#3VHTVanguard

#4IYHiShares

#5IXJiShares

calmest ride

#6XBISPDR

#7IHIiShares

lost money

Ranked by return above cash for each unit of bumpiness (Sharpe ratio) · cash = 3.8%

IDNA

Cost

Today

$47a year per $10,000

XLV

VHT

XBI

$35

IYH

$37

IHI

$37

IXJ

$38

IDNA

$47

Expense ratio 0.47%, taken from the fund’s value

IDNA

Volatility & Beta

31.0%annual volatility

S&P 500 volatility13.7%

Downside volatility18.2%

Beta vs SPY1.10

Correlation vs SPY0.49

Beta rank, lowest first, of 7#6

Daily total returns × √252 · past 254 trading days

IDNA

Max Drawdown

−10.6%peak to trough

Peak closeFeb 27, 2026

Current drawdown−1.3%

Worst day−6.18% · Nov 5

Closing prices, dividends in

IDNA

Up / Down Capture

84%down capture vs SPY

Down days

84%

Up days

143%

S&P 500

100%

Up ÷ down capture1.70

Up days55.1% (S&P 52.4%)

Average daily move on SPY up days and down days

IDNA

Sharpe & Sortino vs Peers

Fund	Sharpe	Sortino	Volatility	Max DD	Beta	Fee / $10k
IDNA	2.42	4.12	31.0%	−10.6%	1.10	$47
XLV	1.66	2.85	16.9%	−10.5%	0.31	$8
VHT	1.63	2.77	16.4%	−10.4%	0.39	$9
IYH	1.61	2.73	17.0%	−10.6%	0.36	$37
IXJ	1.46	2.46	16.4%	−10.8%	0.36	$38
XBI	1.40	2.12	30.1%	−14.9%	1.15	$35
IHI	−0.33	−0.50	22.1%	−26.1%	0.47	$37

Sharpe = (return − 3.8% cash) ÷ volatility · Sortino uses downside volatility only

IDNA

Trading

Today

+3.15%above its holdings’ value

Close$43.57

NAV$42.24

Fee per $10,000$47 a year

Avg. volume 30D198K shares

Premium / discount history starts once daily NAV is saved

Close vs net asset value, Nov 9

The Details

IDNA

Fund Facts

Today

2019launched Jun 11

Tracks[…]

Exchange · CUSIPAMEX · 46435U192

StructureETF

Leverage1x

Cost on $10,000$47 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

iShares IDNA · fund facts · as of Nov 10, 2026

IDNA

Payouts by Year

$0.13per share, Jun 2026

Distribution yield0.6%

PaidTwice a year

Latest ex-date · paidJun 15 · Jun 18, 2026

12 payouts added up$1.46 a share

iShares IDNA · distributions by ex-date · 2019–2026

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

SEC reported portfolio · 2026-07-31 ↗SEC reported portfolio · 2026-04-30 ↗SEC reported portfolio · 2026-01-31 ↗SEC reported portfolio · 2025-10-31 ↗summary prospectus · SEC 497K ↗

Trading & Liquidity

Net asset value$42.24

Premium / discount[…]

Median spread · 30D[…]

Volume today252K

Average volume · 30D198K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.47%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$47.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Jun 15, 2026	Jun 18, 2026	$0.13
Dec 16, 2025	Dec 19, 2025	$0.16
Jun 16, 2025	Jun 20, 2025	$0.15
Dec 17, 2024	Dec 20, 2024	$0.11
Jun 11, 2024	Jun 17, 2024	$0.11
Dec 20, 2023	Dec 27, 2023	$0.17
Jun 7, 2023	Jun 13, 2023	$0.0708
Jun 9, 2022	Jun 15, 2022	$0.14
Dec 13, 2021	Dec 17, 2021	$0.26
Jun 10, 2021	Jun 16, 2021	$0.0521
Dec 14, 2020	Dec 18, 2020	$0.0362
Jun 15, 2020	Jun 19, 2020	$0.0837

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