T. Rowe PriceSectorsHealth Care
T. Rowe Price Biotech ETFTDNA
| Returns | 1D | 1M | 3M | YTD | 1Y | 3Y | 5Y | MAX |
|---|---|---|---|---|---|---|---|---|
| Total return | +3.4% | +4.9% | — | — | — | — | — | −3.0% |
| Peer average | +0.8% | +5.8% | +2.9% | +20.5% | +29.5% | +75.3% | +27.5% | — |
| S&P 500 · VOO | +0.3% | −5.0% | −4.6% | +8.7% | +9.8% | +80.8% | +71.8% | — |
TDNA in One Breath
TDNA Among Health Care ETFs
YTDEnd-of-day Nov 8, 2026 · 33 Health care ETFs by YTD
$10,000 in TDNA
5Y$10,000 in TDNA became
$9,698
In the S&P 500 (VOO)
$9,668
Total return, dividends in · Sep 17, 2026 – Nov 6, 2026 · S&P 500 uses VOO
TDNA’s Top Holdings
TodayARGX5.3%KYMR4.9%KOD2.8%INSM2.6%MRNA2.5%PCVX2.3%RYTM2.2%UTHR2.2%RVMD2.2%NTRA2.1%VRTX2.1%SYRE2.0%MIRM2.0%BBIO2.0%DNTH1.9%PRAX1.8%ALKS1.8%CGON1.7%CYTK1.7%SRRK1.7%ARWR1.5%64 more
BiotechnologyMedical - DiagnosticsDrug Manufacturers - Specialty
T. Rowe Price TDNA · 86 holdings · tile size = share of the fund · as of Nov 6, 2026
What TDNA Holds
TodayBiotechnology88.8%
ARGX 5.3 · KYMR 4.9 · KOD 2.8 · INSM 2.6 · MRNA 2.5 · PCVX 2.3 · RYTM 2.2
Medical - Diagnostics & Research4.1%
NTRA 2.1 · GRAL 1.1 · VCYT · GH
Drug Manufacturers - General3.4%
BIIB 1.3 · AMGN 1.1 · GILD.TO 1.0
Drug Manufacturers - Specialty & Generic1.8%
ALKS 1.8
Other holdings2.0%
FTH · LYCA · CTY
T. Rowe Price TDNA · share of the fund by industry · as of Nov 6, 2026
Argenx’s Share of TDNA
Today5.3%
$53 of every $1,000 in TDNA is Argenx
Argenx held by TDNA
$589K
T. Rowe Price TDNA · each square = $10 of $1,000 · as of Nov 6, 2026
TDNA’s Share of Health Care ETFs
Today0.0%
of the $110B in 39 Health care ETFs
$11.1M0.0%
$49.9B45.4%
$19.1B17.3%
$41.1B37.3%
Health care ETF AUM · Nov 8, 2026
TDNA Fee per $100 vs Peers
TodayExpense ratio · Health care peers · Nov 8, 2026
Inside TDNA
85 holdings · as of Nov 6, 2026TDNA
T. Rowe Price Biotech ETF
Today| # | Ticker | Company | Weight ▼ |
|---|---|---|---|
| 1 | ARGX | Argenx SE | 5.30% |
| 2 | KYMR | Kymera Therapeutics 0001 | 4.86% |
| 3 | KOD | Kodiak Sciences 0001 | 2.76% |
| 4 | INSM | Insmed 01 | 2.59% |
| 5 | MRNA | Moderna 0001 | 2.50% |
| 6 | PCVX | Vaxcyte 001 | 2.31% |
| 7 | RYTM | Rhythm Pharmaceuticals | 2.19% |
| 8 | UTHR | United Therapeutics 01 | 2.17% |
| 9 | RVMD | Revolution Medicines | 2.16% |
| 10 | NTRA | Natera | 2.14% |
BiotechnologyMedical - DiagnosticsDrug Manufacturers - GeneralDrug Manufacturers - SpecialtyOther
T. Rowe Price TDNA · current holdings by weight · as of Nov 6, 2026 · each tile is one holding · top 20 = 47.7%
All TDNA Holdings
86 holdings · as of Nov 6, 2026TDNA
TDNA’s Holdings
Today| # | ||||||
|---|---|---|---|---|---|---|
| 1 | ARGXArgenx SE | Healthcare | 5.30% | $529.60 | 637 | $570K |
| 2 | KYMRKymera Therapeutics 0001 | Healthcare | 4.86% | $486.07 | 4,083 | $523K |
| 3 | KODKodiak Sciences 0001 | Healthcare | 2.76% | $275.63 | 3,259 | $297K |
| 4 | INSMInsmed 01 | Healthcare | 2.59% | $259.41 | 2,567 | $279K |
| 5 | MRNAModerna 0001 | Healthcare | 2.50% | $250.38 | 1,116 | $269K |
| 6 | PCVXVaxcyte 001 | Healthcare | 2.31% | $231.12 | 4,017 | $249K |
| 7 | RYTMRhythm Pharmaceuticals | Healthcare | 2.19% | $219.17 | 2,246 | $236K |
| 8 | UTHRUnited Therapeutics 01 | Healthcare | 2.17% | $217.09 | 413 | $234K |
| 9 | RVMDRevolution Medicines | Healthcare | 2.16% | $215.74 | 1,307 | $232K |
| 10 | NTRANatera | Healthcare | 2.14% | $213.95 | 633 | $230K |
| 11 | VRTXVertex Pharmaceuticals 01 | Healthcare | 2.10% | $210.20 | 417 | $226K |
| 12 | SYRESpyre Therapeutics 0001 | Healthcare | 2.03% | $203.46 | 2,267 | $219K |
| 13 | MIRMMirum Pharmaceuticals | Healthcare | 1.99% | $199.47 | 2,295 | $215K |
| 14 | BBIOBridgebio Pharma | Healthcare | 1.99% | $199.09 | 2,885 | $214K |
| 15 | DNTHDianthus Therapeutics 001 | Healthcare | 1.94% | $194.37 | 2,520 | $209K |
T. Rowe Price TDNA · every reported holding · per $10,000 = dollars of each holding in a $10,000 stake · as of Nov 6, 2026
How It Compares
TDNA
T. Rowe Price Biotech ETF’s Peers
1YHealth care peers · Past-year and ytd returns · as of Nov 8, 2026 · sorted by AUM
Head to Head
Put TDNA head to head with XLV →XLV vs TDNA
YTDYear to date
Level
Past year
Level
Fee
XLV winslower fee
Yield
XLV wins+1.4 pts
AUM
XLV4488.9× more
2–0XLV wins
SPDR XLV and T. Rowe Price TDNA · year-to-date · as of Nov 8, 2026 · AUM not scored
TDNA vs Its Peer Average
YTDTDNAAvsBPeer average
1D+3.4%+0.8%
1M+4.9%+5.8%
3M[…]+2.9%
YTD[…]+20.5%
1Y[…]+29.5%
3Y[…]+75.3%
5Y[…]+27.5%
1–1level
38 Health care peers · each row scaled to its leader
How Bumpy Is TDNA?
TDNA
How Bumpy
1YNot enough history yet: TDNA needs a year of prices.
T. Rowe Price TDNA · daily prices vs the S&P 500
The Details
TDNA
Fund Facts
Today2026launched Sep 16
Tracks[…]
Exchange · CUSIPNASDAQ · 87283Q610
StructureETF
Leverage1x
Cost on $10,000$55 a year
Go deeper
T. Rowe Price TDNA · fund facts · as of Nov 8, 2026
TDNA
Payouts by Year
Today$0no payouts on record
TDNA does not pay a distribution.
Distribution yield0.0%
Paid[…]
Latest ex-date · paid[…]
12 payouts added up[…]
T. Rowe Price TDNA · distributions by ex-date
All Fund FactsDocuments · trading · fees · every payout
Prospectus & Documents
Trading & Liquidity
Net asset value$24.72
Premium / discount[…]
Median spread · 30D[…]
Volume today15K
Average volume · 30D2K
Shares outstanding[…]
Options[…]
Fees & Costs
Net expense ratio0.55%
Gross expense ratio[…]
Management fee[…]
Cost on $10,000 a year$55.00
Our risk indicator4/5
Estimated yearly cost excludes trading costs and assumes constant assets.
Distributions
No payouts on record: […]
Issuer contentFrom T. Rowe PriceHear the strategy from the people behind TDNA.No issuer videos have been published for this fund.Are you the issuer? Claim this fund →