State Street SPDR S&P Biotech ETFXBI

SPDRSectorsHealth Care#36 of 264 by YTD

$148.40

−6.7% last session

+21.8% YTD

Data as of 11/5/20264:00 PM ET · End-of-day

Dividend-adjusted total return · S&P 500 uses VOO · Oct 31, 2023 – Nov 5, 2026XBIS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	−6.7%	−1.2%	−5.7%	+21.8%	+37.9%	+125.5%	+18.4%	+816.6%
Peer average	−3.4%	+4.6%	+3.5%	+19.7%	+29.0%	+75.3%	+27.3%	—
S&P 500 · VOO	−4.4%	−5.7%	−4.9%	+8.4%	+9.8%	+82.2%	+71.6%	—

Key Statistics

Open all fund facts →

AUM: $10.6B
Expense ratio: 0.35%
Distribution yield: 0.4%
NAV: $154.81
Volume: 13.7M
Avg. volume 30D: 9.6M
High today: $157.61
Low today: $148.25
Previous close: $159.10
52-week high: $169.89
52-week low: $106.30
Our risk indicator: 4/5

XBI in One Breath

XBI Among Health Care ETFs

YTD

#1IDNAiShares+58.8%$354M

#2ARKGARK+54.0%$2.2B

#3XHSSPDR+37.9%$231M

#4BBHVanEck+32.6%$538M

#5FTXHFirst Trust+31.5%$1.2B

#6BBPVirtus+26.9%$134M

#7PSCHInvesco+26.6%$179M

#8IHEiShares+25.6%$1.7B

#13XBISPDR+21.8%$10.6B

End-of-day Nov 6, 2026 · 33 Health care ETFs by YTD

$10,000 in XBI

$10,000 in XBI became

$11,836

In the S&P 500 (VOO)

$17,156

Total return, dividends in · Oct 28, 2021 – Nov 5, 2026 · S&P 500 uses VOO

XBI’s Top Holdings

Today

MRNAModerna2.7%EXEL1.8%AMGN1.7%HALO1.7%BIIB1.7%UTHR1.7%GILD1.7%NTRA1.7%ABBV1.7%REGN1.6%SYRE1.6%TWST1.6%TGTX1.6%ORKA1.6%NBIX1.5%VRTX1.5%BBIO1.5%PTCT1.5%ALKS1.4%KYMR1.4%PTGX1.4%INCY1.4%

MRNAModerna2.7%EXEL1.8%AMGN1.7%HALO1.7%BIIB1.7%UTHR1.7%GILD1.7%NTRA1.7%ABBV1.7%REGN1.6%SYRE1.6%TWST1.6%

BiotechnologyDrug Manufacturers - GeneralMedical - DiagnosticsDrug Manufacturers - Specialty

SPDR XBI · 165 holdings · top 22 shown · tile size = share of the fund · as of Nov 5, 2026

What XBI Holds

Today

Biotechnology78.4%

MRNA 2.7 · EXEL 1.8 · HALO 1.7 · UTHR 1.7 · REGN 1.6 · SYRE 1.6 · TWST 1.6

Drug Manufacturers - General6.8%

AMGN 1.7 · BIIB 1.7 · GILD 1.7 · ABBV 1.7

Medical - Diagnostics & Research5.3%

NTRA 1.7 · GRAL 1.4 · VCYT 1.2 · CDNA 1.1

Drug Manufacturers - Specialty & Generic1.4%

ALKS 1.4

Financial - Capital Markets0.6%

PURR

Other holdings7.4%

ANNX

SPDR XBI · share of the fund by industry · as of Nov 5, 2026

Moderna’s Share of XBI

Today

2.7%

$27 of every $1,000 in XBI is Moderna

Moderna held by XBI

$286M

Most Moderna per dollar

IDNA14.6%

GNOM12.7%

GNMX11.2%

BBH7.6%

SPDR XBI · each square = $10 of $1,000 · as of Nov 5, 2026

XBI’s Share of Health Care ETFs

Today

9.6%

of the $110B in 39 Health care ETFs

XBI$10.6B9.6%

XLV$49.1B44.7%

VHT$19.1B17.4%

36 others$31.0B28.3%

Health care ETF AUM · Nov 6, 2026

XBI Fee per $100 vs Peers

Today

$0.35a year
per $100

$35 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IHI$0.37

IXJ$0.38

Expense ratio · Health care peers · Nov 6, 2026

Inside XBI

165 holdings · as of Nov 5, 2026

XBI

State Street SPDR S&P Biotech ETF

Today

Biotechnology78.4%MRNAEXELHALOUTHRREGNSYRE83 more holdings67.2% of the fundDrug Manufacturers - General6.8%AMGNBIIBGILDABBVMedical - Diagnostics5.3%NTRAGRALVCYTCDNAALKSPURROther7.4%

#	Ticker	Company	Weight ▼
1	MRNA	Moderna	2.71%
2	EXEL	Exelixis	1.77%
3	AMGN	Amgen	1.74%
4	HALO	Halozyme Therapeutics	1.73%
5	BIIB	Biogen	1.72%
6	UTHR	United Therapeutics	1.71%
7	GILD	Gilead Sciences	1.70%
8	NTRA	Natera	1.68%
9	ABBV	Abbvie	1.67%
10	REGN	Regeneron Pharmaceuticals	1.64%

See all 167 holdings ↓

BiotechnologyDrug Manufacturers - GeneralMedical - DiagnosticsDrug Manufacturers - SpecialtyFinancial - Capital MarketsOther

SPDR XBI · current holdings by weight · as of Nov 5, 2026 · each tile is one holding · top 20 = 33.3%

All XBI Holdings

167 holdings · as of Nov 5, 2026

XBI

XBI’s Holdings

Today

#
1	MRNAModerna	Healthcare	2.71%	$271.09	1.1M	$295.0M
2	EXELExelixis	Healthcare	1.77%	$177.45	2.6M	$193.1M
3	AMGNAmgen	Healthcare	1.74%	$174.00	391K	$189.4M
4	HALOHalozyme Therapeutics	Healthcare	1.73%	$172.68	1.4M	$187.9M
5	BIIBBiogen	Healthcare	1.72%	$171.80	725K	$187.0M
6	UTHRUnited Therapeutics	Healthcare	1.71%	$170.84	302K	$185.9M
7	GILDGilead Sciences	Healthcare	1.70%	$170.44	1.0M	$185.5M
8	NTRANatera	Healthcare	1.68%	$168.43	463K	$183.3M
9	ABBVAbbvie	Healthcare	1.67%	$167.19	609K	$182.0M
10	REGNRegeneron Pharmaceuticals	Healthcare	1.64%	$163.94	189K	$178.4M
11	SYRESpyre Therapeutics	Healthcare	1.62%	$162.09	1.8M	$176.4M
12	TWSTTwist Bioscience	Healthcare	1.62%	$161.61	1.2M	$175.9M
13	TGTXTG Therapeutics	Healthcare	1.60%	$160.45	2.8M	$174.6M
14	ORKAOruka Therapeutics	Healthcare	1.58%	$157.68	1.7M	$171.6M
15	NBIXNeurocrine Biosciences	Healthcare	1.52%	$152.28	985K	$165.7M

SPDR XBI · every reported holding · per $10,000 = dollars of each holding in a $10,000 stake · as of Nov 5, 2026

How It Compares

XBI

State Street SPDR S&P Biotech ETF’s Peers

YTD


XLV	SPDRRead Desk	0.08%	+20.9%	+29.6%	$49.1B
VHT	VanguardRead Desk	0.09%	+19.7%	+28.0%	$19.1B
XBI	SPDRThis fundRead Desk	0.35%	+21.8%	+37.9%	$10.6B
IYH	iSharesRead Desk	0.37%	+20.3%	+28.8%	$4.9B
IXJ	iSharesRead Desk	0.38%	+19.7%	+28.6%	$4.7B
IHI	iSharesRead Desk	0.37%	−2.7%	−0.4%	$4.1B

Health care peers · YTD and past-year returns · as of Nov 6, 2026 · sorted by AUM

Head to Head

Put XBI head to head with XLV →

XLV vs XBI

YTD

XLVSPDR · Health careXBISPDR · Health care

Year to date

+20.9%

+21.8%

XBI wins+0.9 pts

Past year

+29.6%

+37.9%

XBI wins+8.4 pts

Fee

0.08%

0.35%

XLV winslower fee

Yield

1.4%

0.4%

XLV wins+1.0 pt

AUM

$49.1B

$10.6B

XLV4.7× more

2–2level

SPDR XLV and SPDR XBI · year-to-date · as of Nov 6, 2026 · AUM not scored

XBI vs VOO

YTD

XBI · SPDR S&P Biotech

+21.8%

VOO · S&P 500

+8.4%

Gap

13.4 pts

SPDR XBI and Vanguard VOO · YTD total return · as of Nov 6, 2026

XBI vs Its Peer Average

YTD

XBIAvsBPeer average

1D−6.7%−3.4%

1M−1.2%+4.6%

3M−5.7%+3.5%

YTD+21.8%+19.7%

1Y+37.9%+29.0%

3Y+125.5%+75.3%

5Y+18.4%+27.3%

3–4Peer average wins

38 Health care peers · each row scaled to its leader

The Details

XBI

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y29.92%

Deepest drop · 1Y−14.9%

Lowest point · 5Y−49.3%

52-week range

$148.40

$106.30−12.6% from the high$169.89

SPDR XBI · past-year price moves · as of Nov 6, 2026

XBI

Fund Facts

Today

2006launched Jan 31

Tracks[…]

Exchange · CUSIPAMEX · 78464A870

StructureETF

Leverage1x

Cost on $10,000$35 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

SPDR XBI · fund facts · as of Nov 6, 2026

XBI

Payouts by Year

12Y

$0.14per share, Jun 2026

Distribution yield0.4%

PaidEvery quarter

Latest ex-date · paidJun 22 · Jun 24, 2026

12 payouts added up$0.95 a share

SPDR XBI · distributions by ex-date · 2014–2026

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

summary prospectus · SEC 497K ↗SEC reported portfolio · 2026-06-30 ↗SEC reported portfolio · 2026-03-31 ↗SEC reported portfolio · 2025-12-31 ↗SEC reported portfolio · 2025-09-30 ↗summary prospectus · SEC 497K ↗summary prospectus · SEC 497K ↗SEC reported portfolio · 2025-06-30 ↗SEC reported portfolio · 2025-03-31 ↗SEC reported portfolio · 2024-12-31 ↗SEC reported portfolio · 2024-09-30 ↗

Trading & Liquidity

Net asset value$154.81

Premium / discount[…]

Median spread · 30D[…]

Volume today13.7M

Average volume · 30D9.6M

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.35%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$35.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Jun 22, 2026	Jun 24, 2026	$0.14
Dec 22, 2025	Dec 24, 2025	$0.41
Sep 22, 2025	Sep 24, 2025	$0.0267
Jun 23, 2025	Jun 25, 2025	$0.0073
Mar 24, 2025	Mar 26, 2025	$0.0053
Dec 23, 2024	Dec 26, 2024	$0.0027
Sep 23, 2024	Sep 25, 2024	$0.0152
Jun 24, 2024	Jun 26, 2024	$0.11
Dec 18, 2023	Dec 21, 2023	$0.0139
Jun 20, 2023	Jun 23, 2023	$0.0026
Mar 22, 2021	Mar 25, 2021	$0.0400
Dec 21, 2020	Dec 24, 2020	$0.18

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