T. Rowe Price Biotech ETFTDNA

$23.90

−6.2% last session

[…] YTD

Data as of 11/5/20264:00 PM ET · End-of-day

1D 1M3MYTD1Y3Y5YMAX

Dividend-adjusted return from the previous close · S&P 500 uses VOOTDNAS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	−6.2%	0.0%	—	—	—	—	—	−6.2%
Peer average	−3.4%	+4.6%	+3.5%	+19.7%	+29.0%	+75.3%	+27.3%	—
S&P 500 · VOO	−4.4%	−5.7%	−4.9%	+8.4%	+9.8%	+82.2%	+71.6%	—

Key Statistics

Open all fund facts →

AUM: $11M
Expense ratio: 0.55%
Distribution yield: 0.0%
NAV: $25.48
Volume: 1K
Avg. volume 30D: 2K
High today: $24.66
Low today: $23.90
Previous close: $25.48
52-week high: $25.68
52-week low: $22.72
Our risk indicator: 4/5

TDNA in One Breath

TDNA Among Health Care ETFs

YTD

#1IDNAiShares+58.8%$335M

#2ARKGARK+54.0%$2.2B

#3XHSSPDR+37.9%$243M

#4BBHVanEck+32.6%$519M

#5FTXHFirst Trust+31.5%$1.2B

#6BBPVirtus+26.9%$134M

#7PSCHInvesco+26.6%$187M

#8IHEiShares+25.6%$1.6B

#9IHFiShares+24.9%$1.5B

End-of-day Nov 6, 2026 · 33 Health care ETFs by YTD

$10,000 in TDNA

$10,000 in TDNA became

$9,376

In the S&P 500 (VOO)

$9,639

Total return, dividends in · Sep 17, 2026 – Nov 5, 2026 · S&P 500 uses VOO

TDNA’s Top Holdings

Today

ARGX5.2%KYMR4.9%KOD2.8%MRNA2.5%INSM2.5%PCVX2.3%RVMD2.3%UTHR2.2%RYTM2.2%NTRA2.2%VRTX2.0%BBIO2.0%SYRE2.0%MIRM1.9%DNTH1.9%PRAX1.9%CYTK1.8%ALKS1.7%CGON1.7%SRRK1.6%ARWR1.6%64 more

ARGX5.2%KYMR4.9%KOD2.8%MRNAINSMPCVX2.3%RVMD2.3%UTHR2.2%RYTM2.2%NTRA2.2%VRTX2.0%74 more

BiotechnologyMedical - DiagnosticsDrug Manufacturers - Specialty

T. Rowe Price TDNA · 86 holdings · tile size = share of the fund · as of Nov 5, 2026

What TDNA Holds

Today

Biotechnology88.4%

ARGX 5.2 · KYMR 4.9 · KOD 2.8 · MRNA 2.5 · INSM 2.5 · PCVX 2.3 · RVMD 2.3

Medical - Diagnostics & Research4.7%

NTRA 2.2 · GRAL 1.3 · VCYT · GH

Drug Manufacturers - General3.3%

BIIB 1.2 · AMGN 1.1 · GILD.TO 1.0

Drug Manufacturers - Specialty & Generic1.7%

ALKS 1.7

Other holdings1.9%

FTH · LYCA · CTY

T. Rowe Price TDNA · share of the fund by industry · as of Nov 5, 2026

Argenx’s Share of TDNA

Today

5.2%

$52 of every $1,000 in TDNA is Argenx

Argenx held by TDNA

$593K

Most Argenx per dollar

TDNA5.2%

MEDI4.9%

PJIO4.8%

IBRN4.3%

T. Rowe Price TDNA · each square = $10 of $1,000 · as of Nov 5, 2026

TDNA’s Share of Health Care ETFs

Today

0.0%

of the $112B in 39 Health care ETFs

TDNA$11.5M0.0%

XLV$50.9B45.4%

VHT$19.1B17.0%

36 others$42.1B37.5%

Health care ETF AUM · Nov 6, 2026

TDNA Fee per $100 vs Peers

Today

$0.55a year
per $100

$55 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

TDNA$0.55

Expense ratio · Health care peers · Nov 6, 2026

Inside TDNA

85 holdings · as of Nov 5, 2026

TDNA

T. Rowe Price Biotech ETF

Today

Biotechnology88.4%ARGX5.2%KYMR4.9%KOD2.8%MRNA2.5%INSM2.5%PCVX2.3%RVMD2.3%UTHR2.2%RYTM2.2%VRTX2.0%BBIO2.0%SYREMIRMDNTH60 more holdings51.9% of the fundMedical - Diagnostics4.7%NTRAGRALVCYTGHDrug Manufacturers - General3.3%BIIBAMGNGILD.ALKS

Biotechnology88.4%ARGX5.2%KYMR4.9%KOD2.8%MRNAINSM68 more holdings68.3% of the fundNTRA GRALVCYTBIIBAMGNGILD.ALKS

#	Ticker	Company	Weight ▼
1	ARGX	Argenx SE	5.17%
2	KYMR	Kymera Therapeutics 0001	4.85%
3	KOD	Kodiak Sciences 0001	2.80%
4	MRNA	Moderna 0001	2.51%
5	INSM	Insmed 01	2.46%
6	PCVX	Vaxcyte 001	2.30%
7	RVMD	Revolution Medicines	2.28%
8	UTHR	United Therapeutics 01	2.19%
9	RYTM	Rhythm Pharmaceuticals	2.17%
10	NTRA	Natera	2.16%

See all 86 holdings ↓

BiotechnologyMedical - DiagnosticsDrug Manufacturers - GeneralDrug Manufacturers - SpecialtyOther

T. Rowe Price TDNA · current holdings by weight · as of Nov 5, 2026 · each tile is one holding · top 20 = 47.3%

All TDNA Holdings

86 holdings · as of Nov 5, 2026

TDNA

TDNA’s Holdings

Today

#
1	ARGXArgenx SE	Healthcare	5.17%	$517.39	637	$593K
2	KYMRKymera Therapeutics 0001	Healthcare	4.85%	$485.14	4,083	$556K
3	KODKodiak Sciences 0001	Healthcare	2.80%	$279.97	3,259	$321K
4	MRNAModerna 0001	Healthcare	2.51%	$251.46	1,116	$288K
5	INSMInsmed 01	Healthcare	2.46%	$246.25	2,567	$282K
6	PCVXVaxcyte 001	Healthcare	2.30%	$230.08	4,017	$264K
7	RVMDRevolution Medicines	Healthcare	2.28%	$227.62	1,307	$261K
8	UTHRUnited Therapeutics 01	Healthcare	2.19%	$219.16	413	$251K
9	RYTMRhythm Pharmaceuticals	Healthcare	2.17%	$216.79	2,246	$249K
10	NTRANatera	Healthcare	2.16%	$215.86	633	$248K
11	VRTXVertex Pharmaceuticals 01	Healthcare	2.00%	$199.66	417	$229K
12	BBIOBridgebio Pharma	Healthcare	1.96%	$195.97	2,885	$225K
13	SYRESpyre Therapeutics 0001	Healthcare	1.96%	$195.80	2,267	$225K
14	MIRMMirum Pharmaceuticals	Healthcare	1.94%	$194.08	2,295	$223K
15	DNTHDianthus Therapeutics 001	Healthcare	1.89%	$188.58	2,520	$216K

T. Rowe Price TDNA · every reported holding · per $10,000 = dollars of each holding in a $10,000 stake · as of Nov 5, 2026

How It Compares

TDNA

T. Rowe Price Biotech ETF’s Peers

YTD

		Trend
XLV	SPDRRead Desk		0.08%	+20.9%	+29.6%	$50.9B
VHT	VanguardRead Desk		0.09%	+19.7%	+28.0%	$19.1B
XBI	SPDRRead Desk		0.35%	+21.8%	+37.9%	$10.9B
IYH	iSharesRead Desk		0.37%	+20.3%	+28.8%	$4.7B
IXJ	iSharesRead Desk		0.38%	+19.7%	+28.6%	$4.6B
TDNA	T. Rowe PriceThis fundRead Desk	New fund	0.55%	new	new	$11M

Health care peers · YTD and past-year returns · as of Nov 6, 2026 · sorted by AUM

Head to Head

Put TDNA head to head with XLV →

XLV vs TDNA

YTD

XLVSPDR · Health careTDNAT. Rowe Price · Health care

Year to date

+20.9%

[…]

Level

Past year

+29.6%

[…]

Level

Fee

0.08%

0.55%

XLV winslower fee

Yield

1.4%

0.0%

XLV wins+1.4 pts

AUM

$50.9B

$11.5M

XLV4442.0× more

2–0XLV wins

SPDR XLV and T. Rowe Price TDNA · year-to-date · as of Nov 6, 2026 · AUM not scored

TDNA vs Its Peer Average

YTD

TDNAAvsBPeer average

1D−6.2%−3.4%

1M0.0%+4.6%

3M[…]+3.5%

YTD[…]+19.7%

1Y[…]+29.0%

3Y[…]+75.3%

5Y[…]+27.3%

0–2Peer average wins

38 Health care peers · each row scaled to its leader

The Details

TDNA

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y[…]

Deepest drop · 1Y[…]

Lowest point · 5Y−10.9%

52-week range

$23.90

$22.72−6.9% from the high$25.68

T. Rowe Price TDNA · past-year price moves · as of Nov 6, 2026

TDNA

Fund Facts

Today

2026launched Sep 16

Tracks[…]

Exchange · CUSIPNASDAQ · 87283Q610

StructureETF

Leverage1x

Cost on $10,000$55 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

T. Rowe Price TDNA · fund facts · as of Nov 6, 2026

TDNA

Payouts by Year

Today

$0no payouts on record

TDNA does not pay a distribution.

Distribution yield0.0%

Paid[…]

Latest ex-date · paid[…]

12 payouts added up[…]

T. Rowe Price TDNA · distributions by ex-date

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

summary prospectus · SEC 497K ↗

Trading & Liquidity

Net asset value$25.48

Premium / discount[…]

Median spread · 30D[…]

Volume today1K

Average volume · 30D2K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.55%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$55.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

No payouts on record: […]

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