T. Rowe Price Biotech ETFTDNA

$25.48

+3.3% last session

[…] YTD

Data as of 11/4/20264:00 PM ET · End-of-day

1D 1M3MYTD1Y3Y5YMAX

Dividend-adjusted total return · S&P 500 uses VOO · Sep 17, 2026 – Nov 4, 2026TDNAS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	+3.3%	+6.1%	—	—	—	—	—	0.0%
Peer average	+2.7%	+8.5%	+8.9%	+24.4%	+33.4%	+84.3%	+34.0%	—
S&P 500 · VOO	+1.6%	−1.6%	0.0%	+13.4%	+13.5%	+91.7%	+81.2%	—

Key Statistics

Open all fund facts →

AUM: $11M
Expense ratio: 0.55%
Distribution yield: 0.0%
NAV: $24.35
Volume: 1K
Avg. volume 30D: 2K
High today: $25.48
Low today: $24.59
Previous close: $24.66
52-week high: $25.68
52-week low: $22.72
Our risk indicator: 4/5

TDNA in One Breath

TDNA Among Health Care ETFs

YTD

#1ARKGARK+71.5%$2.2B

#2IDNAiShares+69.3%$340M

#3XHSSPDR+40.0%$229M

#4BBHVanEck+38.2%$525M

#5FTXHFirst Trust+36.8%$1.2B

#6PSCHInvesco+31.7%$178M

#7XBISPDR+30.6%$10.5B

#8IHEiShares+29.8%$1.6B

#9BBPVirtus+28.5%$132M

End-of-day Nov 5, 2026 · 33 Health care ETFs by YTD

$10,000 in TDNA

$10,000 in TDNA became

$9,996

In the S&P 500 (VOO)

$10,079

Total return, dividends in · Sep 17, 2026 – Nov 4, 2026 · S&P 500 uses VOO

TDNA’s Top Holdings

Today

ARGXArgenx Se5.2%KYMR4.7%KOD2.8%UTHR2.5%INSM2.4%VRTX2.3%NTRA2.3%MRNA2.3%RVMD2.3%BBIO2.1%PCVX2.1%SYRE2.0%PRAX1.9%DNTH1.8%ALKS1.8%CYTK1.8%MIRM1.7%RYTM1.7%TNGX1.6%CGON1.6%ARWR1.6%SRRK1.5%

ARGXArgenx Se5.2%KYMR4.7%KOD2.8%UTHR2.5%INSM2.4%VRTX2.3%NTRA2.3%MRNA2.3%RVMD2.3%BBIO2.1%PCVX2.1%SYRE2.0%

BiotechnologyMedical - DiagnosticsDrug Manufacturers - Specialty

T. Rowe Price TDNA · 0 holdings · tile size = share of the fund · as of Nov 4, 2026

What TDNA Holds

Today

Biotechnology88.7%

ARGX 5.2 · KYMR 4.7 · KOD 2.8 · UTHR 2.5 · INSM 2.4 · VRTX 2.3 · MRNA 2.3

Medical - Diagnostics & Research4.8%

NTRA 2.3 · GRAL 1.2 · VCYT · GH

Drug Manufacturers - General3.1%

BIIB 1.2 · AMGN · GILD.TO

Drug Manufacturers - Specialty & Generic1.8%

ALKS 1.8

Other holdings1.6%

LYCA · CTY

T. Rowe Price TDNA · share of the fund by industry · as of Nov 4, 2026

Argenx’s Share of TDNA

Today

5.2%

$52 of every $1,000 in TDNA is Argenx

Argenx held by TDNA

$567K

Most Argenx per dollar

TDNA5.2%

MEDI4.9%

PJIO4.7%

IBRN4.2%

T. Rowe Price TDNA · each square = $10 of $1,000 · as of Nov 4, 2026

TDNA’s Share of Health Care ETFs

Today

0.0%

of the $109B in 39 Health care ETFs

TDNA$11.0M0.0%

XLV$49.1B45.0%

VHT$19.1B17.5%

36 others$40.8B37.4%

Health care ETF AUM · Nov 5, 2026

TDNA Fee per $100 vs Peers

Today

$0.55a year
per $100

$55 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

TDNA$0.55

Expense ratio · Health care peers · Nov 5, 2026

Inside TDNA

as of Nov 4, 2026

TDNA

T. Rowe Price Biotech ETF

Today

Biotechnology88.7%ARGX5.2%KYMR4.7%KOD2.8%UTHR2.5%INSM2.4%VRTX2.3%MRNA2.3%RVMD2.3%BBIO2.1%PCVX2.1%SYRE2.0%PRAXDNTHCYTK63 more holdings52.6% of the fundMedical - Diagnostics4.8%NTRA2.3%GRALVCYTGHDrug Manufacturers - General3.1%BIIBAMGNALKS

Biotechnology88.7%ARGX5.2%KYMR4.7%KOD2.8%UTHRINSM71 more holdings68.8% of the fundNTRA GRALVCYTBIIBAMGNGILD.ALKS

#	Ticker	Company	Weight ▼
1	ARGX	Argenx SE	5.17%
2	KYMR	Kymera Therapeutics 0001	4.67%
3	KOD	Kodiak Sciences 0001	2.84%
4	UTHR	United Therapeutics 01	2.48%
5	INSM	Insmed 01	2.42%
6	VRTX	Vertex Pharmaceuticals 01	2.33%
7	NTRA	Natera	2.31%
8	MRNA	Moderna 0001	2.30%
9	RVMD	Revolution Medicines	2.29%
10	BBIO	Bridgebio Pharma	2.07%

BiotechnologyMedical - DiagnosticsDrug Manufacturers - GeneralDrug Manufacturers - SpecialtyOther

T. Rowe Price TDNA · current holdings by weight · as of Nov 4, 2026 · each tile is one holding · top 20 = 46.8%

How It Compares

TDNA

T. Rowe Price Biotech ETF’s Peers

YTD

		Trend
XLV	SPDRRead Desk		0.08%	+24.0%	+33.5%	$49.1B
VHT	VanguardRead Desk		0.09%	+23.3%	+32.1%	$19.1B
XBI	SPDRRead Desk		0.35%	+30.6%	+45.4%	$10.5B
IYH	iSharesRead Desk		0.37%	+23.7%	+32.8%	$4.7B
IXJ	iSharesRead Desk		0.38%	+19.7%	+28.6%	$4.6B
TDNA	T. Rowe PriceThis fundRead Desk	New fund	0.55%	new	new	$11M

Health care peers · YTD and past-year returns · as of Nov 5, 2026 · sorted by AUM

Head to Head

Put TDNA head to head with XLV →

XLV vs TDNA

YTD

XLVSPDR · Health careTDNAT. Rowe Price · Health care

Year to date

+24.0%

[…]

Level

Past year

+33.5%

[…]

Level

Fee

0.08%

0.55%

XLV winslower fee

Yield

1.3%

0.0%

XLV wins+1.3 pts

AUM

$49.1B

$11.0M

XLV4481.3× more

2–0XLV wins

SPDR XLV and T. Rowe Price TDNA · year-to-date · as of Nov 5, 2026 · AUM not scored

TDNA vs Its Peer Average

YTD

TDNAAvsBPeer average

1D+3.3%+2.7%

1M+6.1%+8.5%

3M[…]+8.9%

YTD[…]+24.4%

1Y[…]+33.4%

3Y[…]+84.3%

5Y[…]+34.0%

1–1level

38 Health care peers · each row scaled to its leader

The Details

TDNA

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y[…]

Deepest drop · 1Y[…]

Lowest point · 5Y−10.9%

52-week range

$25.48

$22.72−0.8% from the high$25.68

T. Rowe Price TDNA · past-year price moves · as of Nov 5, 2026

TDNA

Fund Facts

Today

2026launched Sep 16

Tracks[…]

Exchange · CUSIPNASDAQ · 87283Q610

StructureETF

Leverage1x

Cost on $10,000$55 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

T. Rowe Price TDNA · fund facts · as of Nov 5, 2026

TDNA

Payouts by Year

Today

$0no payouts on record

TDNA does not pay a distribution.

Distribution yield0.0%

Paid[…]

Latest ex-date · paid[…]

12 payouts added up[…]

T. Rowe Price TDNA · distributions by ex-date

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

summary prospectus · SEC 497K ↗

Trading & Liquidity

Net asset value$24.35

Premium / discount[…]

Median spread · 30D[…]

Volume today1K

Average volume · 30D2K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.55%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$55.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

No payouts on record: […]

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