Dividend-adjusted total return · S&P 500 uses VOO · Dec 31, 2025 – Nov 5, 2026XBIS&P 500 · VOO
| Returns | 1D | 1M | 3M | YTD | 1Y | 3Y | 5Y | MAX |
|---|---|---|---|---|---|---|---|---|
| Total return | −6.7% | −1.2% | −5.7% | +21.8% | +37.9% | +125.5% | +18.4% | +816.6% |
| Peer average | −3.4% | +4.6% | +3.5% | +19.7% | +29.0% | +75.3% | +27.3% | — |
| S&P 500 · VOO | −4.4% | −5.7% | −4.9% | +8.4% | +9.8% | +82.2% | +71.6% | — |
Key Statistics
Open all fund facts →- AUM
- $10.6B
- Expense ratio
- 0.35%
- Distribution yield
- 0.4%
- NAV
- $154.81
- Volume
- 13.7M
- Avg. volume 30D
- 9.6M
- High today
- $157.61
- Low today
- $148.25
- Previous close
- $159.10
- 52-week high
- $169.89
- 52-week low
- $106.30
- Our risk indicator
- 4/5
XBI in One Breath
XBI Among Health Care ETFs
YTDEnd-of-day Nov 5, 2026 · 33 Health care ETFs by YTD
$10,000 in XBI
5Y$10,000 in XBI became
$11,836
In the S&P 500 (VOO)
$17,156
Total return, dividends in · Oct 28, 2021 – Nov 5, 2026 · S&P 500 uses VOO
XBI’s Top Holdings
TodayMRNAModerna2.7%EXEL1.8%AMGN1.7%HALO1.7%BIIB1.7%UTHR1.7%GILD1.7%NTRA1.7%ABBV1.7%REGN1.6%SYRE1.6%TWST1.6%TGTX1.6%ORKA1.6%NBIX1.5%VRTX1.5%BBIO1.5%PTCT1.5%ALKS1.4%KYMR1.4%PTGX1.4%INCY1.4%
MRNAModerna2.7%EXEL1.8%AMGN1.7%HALO1.7%BIIB1.7%UTHR1.7%GILD1.7%NTRA1.7%ABBV1.7%REGN1.6%SYRE1.6%TWST1.6%
BiotechnologyDrug Manufacturers - GeneralMedical - DiagnosticsDrug Manufacturers - Specialty
SPDR XBI · 165 holdings · top 22 shown · tile size = share of the fund · as of Nov 5, 2026
What XBI Holds
TodayBiotechnology78.4%
MRNA 2.7 · EXEL 1.8 · HALO 1.7 · UTHR 1.7 · REGN 1.6 · SYRE 1.6 · TWST 1.6
Drug Manufacturers - General6.8%
AMGN 1.7 · BIIB 1.7 · GILD 1.7 · ABBV 1.7
Medical - Diagnostics & Research5.3%
NTRA 1.7 · GRAL 1.4 · VCYT 1.2 · CDNA 1.1
Drug Manufacturers - Specialty & Generic1.4%
ALKS 1.4
Financial - Capital Markets0.6%
PURR
Other holdings7.4%
ANNX
SPDR XBI · share of the fund by industry · as of Nov 5, 2026
Moderna’s Share of XBI
Today2.7%
$27 of every $1,000 in XBI is Moderna
Moderna held by XBI
$286M
SPDR XBI · each square = $10 of $1,000 · as of Nov 5, 2026
XBI’s Share of Health Care ETFs
Today9.6%
of the $110B in 39 Health care ETFs
$10.6B9.6%
$49.1B44.7%
$19.1B17.4%
$31.0B28.3%
Health care ETF AUM · Nov 5, 2026
XBI Fee per $100 vs Peers
TodayExpense ratio · Health care peers · Nov 5, 2026
Inside XBI
165 holdings · as of Nov 5, 2026XBI
State Street SPDR S&P Biotech ETF
Today| # | Ticker | Company | Weight ▼ |
|---|---|---|---|
| 1 | MRNA | Moderna | 2.71% |
| 2 | EXEL | Exelixis | 1.77% |
| 3 | AMGN | Amgen | 1.74% |
| 4 | HALO | Halozyme Therapeutics | 1.73% |
| 5 | BIIB | Biogen | 1.72% |
| 6 | UTHR | United Therapeutics | 1.71% |
| 7 | GILD | Gilead Sciences | 1.70% |
| 8 | NTRA | Natera | 1.68% |
| 9 | ABBV | Abbvie | 1.67% |
| 10 | REGN | Regeneron Pharmaceuticals | 1.64% |
BiotechnologyDrug Manufacturers - GeneralMedical - DiagnosticsDrug Manufacturers - SpecialtyFinancial - Capital MarketsOther
SPDR XBI · current holdings by weight · as of Nov 5, 2026 · each tile is one holding · top 20 = 33.3%
How It Compares
XBI
State Street SPDR S&P Biotech ETF’s Peers
TodayHealth care peers · Today’s and past-year returns · as of Nov 6, 2026 · sorted by AUM
Head to Head
Put XBI head to head with XLV →XLV vs XBI
YTDYear to date
XBI wins+0.9 pts
Past year
XBI wins+8.4 pts
Fee
XLV winslower fee
Yield
XLV wins+1.0 pt
AUM
XLV4.7× more
2–2level
SPDR XLV and SPDR XBI · year-to-date · as of Nov 6, 2026 · AUM not scored
XBI vs VOO
YTDXBI · SPDR S&P Biotech
+21.8%
VOO · S&P 500
+8.4%
Gap
13.4 pts
SPDR XBI and Vanguard VOO · Today total return · as of Nov 6, 2026
XBI vs Its Peer Average
YTDXBIAvsBPeer average
1D−6.7%−3.4%
1M−1.2%+4.6%
3M−5.7%+3.5%
YTD+21.8%+19.7%
1Y+37.9%+29.0%
3Y+125.5%+75.3%
5Y+18.4%+27.3%
3–4Peer average wins
38 Health care peers · each row scaled to its leader
The Details
XBI
Risk
1Y4/5our risk indicator
CalmerBumpier
Volatility · 1Y29.92%
Deepest drop · 1Y−14.9%
Lowest point · 5Y−49.3%
52-week range
$148.40
$106.30−12.6% from the high$169.89
SPDR XBI · past-year price moves · as of Nov 6, 2026
XBI
Fund Facts
Today2006launched Jan 31
Tracks[…]
Exchange · CUSIPAMEX · 78464A870
StructureETF
Leverage1x
Cost on $10,000$35 a year
Go deeper
SPDR XBI · fund facts · as of Nov 6, 2026
XBI
Payouts by Year
12Y$0.14per share, Jun 2026
Distribution yield0.4%
PaidEvery quarter
Latest ex-date · paidJun 22 · Jun 24, 2026
12 payouts added up$0.95 a share
SPDR XBI · distributions by ex-date · 2014–2026
All Fund FactsDocuments · trading · fees · every payout
Prospectus & Documents
summary prospectus · SEC 497K ↗SEC reported portfolio · 2026-06-30 ↗SEC reported portfolio · 2026-03-31 ↗SEC reported portfolio · 2025-12-31 ↗SEC reported portfolio · 2025-09-30 ↗summary prospectus · SEC 497K ↗summary prospectus · SEC 497K ↗SEC reported portfolio · 2025-06-30 ↗SEC reported portfolio · 2025-03-31 ↗SEC reported portfolio · 2024-12-31 ↗SEC reported portfolio · 2024-09-30 ↗
Trading & Liquidity
Net asset value$154.81
Premium / discount[…]
Median spread · 30D[…]
Volume today13.7M
Average volume · 30D9.6M
Shares outstanding[…]
Options[…]
Fees & Costs
Net expense ratio0.35%
Gross expense ratio[…]
Management fee[…]
Cost on $10,000 a year$35.00
Our risk indicator4/5
Estimated yearly cost excludes trading costs and assumes constant assets.
Distributions
| Ex-date | Paid | Per share |
|---|---|---|
| Jun 22, 2026 | Jun 24, 2026 | $0.14 |
| Dec 22, 2025 | Dec 24, 2025 | $0.41 |
| Sep 22, 2025 | Sep 24, 2025 | $0.0267 |
| Jun 23, 2025 | Jun 25, 2025 | $0.0073 |
| Mar 24, 2025 | Mar 26, 2025 | $0.0053 |
| Dec 23, 2024 | Dec 26, 2024 | $0.0027 |
| Sep 23, 2024 | Sep 25, 2024 | $0.0152 |
| Jun 24, 2024 | Jun 26, 2024 | $0.11 |
| Dec 18, 2023 | Dec 21, 2023 | $0.0139 |
| Jun 20, 2023 | Jun 23, 2023 | $0.0026 |
| Mar 22, 2021 | Mar 25, 2021 | $0.0400 |
| Dec 21, 2020 | Dec 24, 2020 | $0.18 |
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