State Street SPDR S&P Biotech ETFXBI

SPDRSectorsHealth Care#35 of 264 by YTD

$154.97

+1.9% last session

+27.2% YTD

Data as of 11/3/20264:00 PM ET · End-of-day

Dividend-adjusted total return · S&P 500 uses VOO · Dec 31, 2025 – Nov 3, 2026XBIS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	+1.9%	−0.8%	+1.3%	+27.2%	+38.1%	+143.2%	+25.8%	+857.2%
Peer average	+0.6%	+4.0%	+6.1%	+21.0%	+29.0%	+81.2%	+28.9%	—
S&P 500 · VOO	+0.3%	−2.6%	−1.7%	+11.5%	+11.9%	+90.9%	+77.5%	—

Key Statistics

Open all fund facts →

AUM: $10.5B
Expense ratio: 0.35%
Distribution yield: 0.4%
NAV: $152.05
Volume: 6.4M
Avg. volume 30D: 9.7M
High today: $156.92
Low today: $152.83
Previous close: $152.05
52-week high: $169.89
52-week low: $106.30
Our risk indicator: 4/5

XBI in One Breath

XBI Among Health Care ETFs

YTD

#1ARKGARK+70.9%$2.2B

#2IDNAiShares+62.8%$340M

#3BBHVanEck+35.0%$525M

#4FTXHFirst Trust+33.8%$1.2B

#5XHSSPDR+32.9%$229M

#6BBPVirtus+29.5%$132M

#7XBISPDR+27.2%$10.5B

#8IHEiShares+26.9%$1.6B

#9PSCHInvesco+25.9%$178M

End-of-day Nov 4, 2026 · 33 Health care ETFs by YTD

$10,000 in XBI

$10,000 in XBI became

$12,576

In the S&P 500 (VOO)

$17,749

Total return, dividends in · Oct 26, 2021 – Nov 3, 2026 · S&P 500 uses VOO

XBI’s Top Holdings

Today

MRNAModerna2.4%TWST2.0%NTRA1.9%HALO1.8%BIIB1.7%AMGN1.7%UTHR1.7%ABBV1.7%SYRE1.6%GILD1.6%EXEL1.6%TGTX1.5%ORKA1.5%GRAL1.5%VRTX1.5%REGN1.5%ALKS1.4%CRSP1.4%PTGX1.4%PTCT1.4%NBIX1.4%KRYS1.3%

MRNAModerna2.4%TWST2.0%NTRA1.9%HALO1.8%BIIB1.7%AMGN1.7%UTHR1.7%ABBV1.7%SYRE1.6%GILD1.6%EXEL1.6%TGTX1.5%

BiotechnologyDrug Manufacturers - GeneralMedical - DiagnosticsDrug Manufacturers - Specialty

SPDR XBI · 165 holdings · top 22 shown · tile size = share of the fund · as of Nov 1, 2026

What XBI Holds

Today

Biotechnology78.3%

MRNA 2.4 · TWST 2.0 · HALO 1.8 · UTHR 1.7 · SYRE 1.6 · EXEL 1.6 · TGTX 1.5

Drug Manufacturers - General6.7%

BIIB 1.7 · AMGN 1.7 · ABBV 1.7 · GILD 1.6

Medical - Diagnostics & Research5.5%

NTRA 1.9 · GRAL 1.5 · VCYT 1.2 · CDNA

Drug Manufacturers - Specialty & Generic1.4%

ALKS 1.4

Financial - Capital Markets0.7%

PURR

Other holdings7.4%

[…]

SPDR XBI · share of the fund by industry · as of Nov 1, 2026

Moderna’s Share of XBI

Today

2.4%

$24 of every $1,000 in XBI is Moderna

Moderna held by XBI

$248M

Most Moderna per dollar

IDNA12.8%

GNOM11.0%

GNMX10.0%

BBH6.7%

SPDR XBI · each square = $10 of $1,000 · as of Nov 1, 2026

XBI’s Share of Health Care ETFs

Today

9.6%

of the $109B in 39 Health care ETFs

XBI$10.5B9.6%

XLV$49.1B45.0%

VHT$19.1B17.5%

36 others$30.3B27.8%

Health care ETF AUM · Nov 4, 2026

XBI Fee per $100 vs Peers

Today

$0.35a year
per $100

$35 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IHI$0.37

IXJ$0.38

Expense ratio · Health care peers · Nov 4, 2026

Inside XBI

165 holdings · as of Nov 1, 2026

XBI

State Street SPDR S&P Biotech ETF

Today

Biotechnology78.3%MRNA2.4%TWST2.0%HALO1.8%UTHR1.7%SYRE1.6%EXELTGTXORKAVRTXREGNCRSPPTGXPTCTNBIX76 more holdings55.7% of the fundDrug Manufacturers - General6.7%BIIBAMGNABBVGILDMedical - Diagnostics5.5%NTRAGRALVCYTCDNAALKSPURROther7.4%

Biotechnology78.3%MRNATWSTHALOUTHRSYREEXEL84 more holdings67.3% of the fundDrug Manufacturers - General6.7%BIIBAMGNABBVGILDMedical - Diagnostics5.5%NTRAGRALVCYTCDNAALKSPURROther7.4%

#	Ticker	Company	Weight ▼
1	MRNA	Moderna	2.36%
2	TWST	Twist Bioscience	1.98%
3	NTRA	Natera	1.89%
4	HALO	Halozyme Therapeutics	1.75%
5	BIIB	Biogen	1.70%
6	AMGN	Amgen	1.69%
7	UTHR	United Therapeutics	1.68%
8	ABBV	Abbvie	1.66%
9	SYRE	Spyre Therapeutics	1.63%
10	GILD	Gilead Sciences	1.63%

BiotechnologyDrug Manufacturers - GeneralMedical - DiagnosticsDrug Manufacturers - SpecialtyFinancial - Capital MarketsOther

SPDR XBI · current holdings by weight · as of Nov 1, 2026 · each tile is one holding · top 20 = 32.8%

How It Compares

XBI

State Street SPDR S&P Biotech ETF’s Peers


XLV	SPDRRead Desk	0.08%	+29.7%	+20.4%	$49.1B
VHT	VanguardRead Desk	0.09%	+28.1%	+19.6%	$19.1B
XBI	SPDRThis fundRead Desk	0.35%	+38.1%	+27.2%	$10.5B
IYH	iSharesRead Desk	0.37%	+28.6%	+19.8%	$4.7B
IXJ	iSharesRead Desk	0.38%	+24.7%	+16.0%	$4.6B
IHI	iSharesRead Desk	0.37%	−5.8%	−8.9%	$3.9B

Health care peers · Past-year and ytd returns · as of Nov 4, 2026 · sorted by AUM

Head to Head

Put XBI head to head with XLV →

XLV vs XBI

YTD

XLVSPDR · Health careXBISPDR · Health care

Year to date

+20.4%

+27.2%

XBI wins+6.9 pts

Past year

+29.7%

+38.1%

XBI wins+8.4 pts

Fee

0.08%

0.35%

XLV winslower fee

Yield

1.4%

0.4%

XLV wins+1.0 pt

AUM

$49.1B

$10.5B

XLV4.7× more

2–2level

SPDR XLV and SPDR XBI · year-to-date · as of Nov 4, 2026 · AUM not scored

XBI vs VOO

XBI · SPDR S&P Biotech

+38.1%

VOO · S&P 500

+11.9%

Gap

26.2 pts

SPDR XBI and Vanguard VOO · 1Y total return · as of Nov 4, 2026

XBI vs Its Peer Average

YTD

XBIAvsBPeer average

1D+1.9%+0.6%

1M−0.8%+4.0%

3M+1.3%+6.1%

YTD+27.2%+21.0%

1Y+38.1%+29.0%

3Y+143.2%+81.2%

5Y+25.8%+28.9%

4–3XBI wins

38 Health care peers · each row scaled to its leader

The Details

XBI

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y29.14%

Deepest drop · 1Y−14.9%

Lowest point · 5Y−48.9%

52-week range

$154.97

$106.30−8.8% from the high$169.89

SPDR XBI · past-year price moves · as of Nov 4, 2026

XBI

Fund Facts

Today

2006launched Jan 31

Tracks[…]

Exchange · CUSIPAMEX · 78464A870

StructureETF

Leverage1x

Cost on $10,000$35 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

SPDR XBI · fund facts · as of Nov 4, 2026

XBI

Payouts by Year

12Y

$0.14per share, Jun 2026

Distribution yield0.4%

PaidEvery quarter

Latest ex-date · paidJun 22 · Jun 24, 2026

12 payouts added up$0.95 a share

SPDR XBI · distributions by ex-date · 2014–2026

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

summary prospectus · SEC 497K ↗SEC reported portfolio · 2026-06-30 ↗SEC reported portfolio · 2026-03-31 ↗SEC reported portfolio · 2025-12-31 ↗SEC reported portfolio · 2025-09-30 ↗summary prospectus · SEC 497K ↗summary prospectus · SEC 497K ↗SEC reported portfolio · 2025-06-30 ↗SEC reported portfolio · 2025-03-31 ↗SEC reported portfolio · 2024-12-31 ↗SEC reported portfolio · 2024-09-30 ↗

Trading & Liquidity

Net asset value$152.05

Premium / discount[…]

Median spread · 30D[…]

Volume today6.4M

Average volume · 30D9.7M

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.35%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$35.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Jun 22, 2026	Jun 24, 2026	$0.14
Dec 22, 2025	Dec 24, 2025	$0.41
Sep 22, 2025	Sep 24, 2025	$0.0267
Jun 23, 2025	Jun 25, 2025	$0.0073
Mar 24, 2025	Mar 26, 2025	$0.0053
Dec 23, 2024	Dec 26, 2024	$0.0027
Sep 23, 2024	Sep 25, 2024	$0.0152
Jun 24, 2024	Jun 26, 2024	$0.11
Dec 18, 2023	Dec 21, 2023	$0.0139
Jun 20, 2023	Jun 23, 2023	$0.0026
Mar 22, 2021	Mar 25, 2021	$0.0400
Dec 21, 2020	Dec 24, 2020	$0.18

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