ALPS Medical Breakthroughs ETFSBIO

ALPSSectorsHealth Care#188 of 264 by YTD

$52.83

−5.3% last session

+3.1% YTD

Data as of 11/5/20264:00 PM ET · End-of-day

Dividend-adjusted total return · S&P 500 uses VOO · Dec 31, 2025 – Nov 5, 2026SBIOS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	−5.3%	−2.4%	−21.9%	+3.1%	+21.0%	+123.3%	+18.2%	+131.0%
Peer average	−3.4%	+4.6%	+3.5%	+19.7%	+29.0%	+75.3%	+27.3%	—
S&P 500 · VOO	−4.4%	−5.7%	−4.9%	+8.4%	+9.8%	+82.2%	+71.6%	—

Key Statistics

Open all fund facts →

AUM: $187M
Expense ratio: 0.50%
Distribution yield: 0.0%
NAV: $55.81
Volume: 20K
Avg. volume 30D: 34K
High today: $55.96
Low today: $52.83
Previous close: $55.81
52-week high: $70.85
52-week low: $43.10
Our risk indicator: 4/5

SBIO in One Breath

SBIO Among Health Care ETFs

YTD

#1IDNAiShares+58.8%$354M

#2ARKGARK+54.0%$2.2B

#3XHSSPDR+37.9%$231M

#4BBHVanEck+32.6%$538M

#5FTXHFirst Trust+31.5%$1.2B

#6BBPVirtus+26.9%$134M

#7PSCHInvesco+26.6%$179M

#8IHEiShares+25.6%$1.7B

#31SBIOALPS+3.1%$187M

End-of-day Nov 5, 2026 · 33 Health care ETFs by YTD

$10,000 in SBIO

$10,000 in SBIO became

$11,821

In the S&P 500 (VOO)

$17,156

Total return, dividends in · Oct 28, 2021 – Nov 5, 2026 · S&P 500 uses VOO

SBIO’s Top Holdings

Today

ORKAOruka Therapeutics4.4%CGON3.9%MANE3.7%TVTX3.2%DNTH3.1%DFTX2.9%EWTX2.7%RLAY2.6%XENE2.5%ACAD2.4%AMLX2.4%DYN2.3%DNLI2.2%VRDN2.2%IRON2.1%IDYA2.0%TARS2.0%XNCR1.7%ZLAB1.7%MBX1.7%NAMS1.6%81 more

ORKA4.4%CGON3.9%MANE3.7%TVTX3.2%DNTH3.1%DFTX2.9%EWTX2.7%RLAY2.6%XENE2.5%ACAD2.4%AMLX2.4%91 more

Biotechnology

ALPS SBIO · 103 holdings · tile size = share of the fund · as of Nov 5, 2026

What SBIO Holds

Today

Biotechnology93.1%

ORKA 4.4 · CGON 3.9 · MANE 3.7 · TVTX 3.2 · DNTH 3.1 · DFTX 2.9 · EWTX 2.7

Medical - Diagnostics & Research0.4%

FLGT

Medical - Devices0.3%

DCTH

Other holdings6.3%

MGTX · SLDB · CADL · DSGN · AVBP · OLMA · ALT

ALPS SBIO · share of the fund by industry · as of Nov 5, 2026

Oruka’s Share of SBIO

Today

4.4%

$44 of every $1,000 in SBIO is Oruka

Oruka held by SBIO

$8.2M

Most Oruka per dollar

SBIO4.4%

DWAS1.6%

KBFR0.3%

ALPS SBIO · each square = $10 of $1,000 · as of Nov 5, 2026

SBIO’s Share of Health Care ETFs

Today

0.2%

of the $110B in 39 Health care ETFs

SBIO$187M0.2%

XLV$49.1B44.7%

VHT$19.1B17.4%

36 others$41.4B37.7%

Health care ETF AUM · Nov 5, 2026

SBIO Fee per $100 vs Peers

Today

$0.50a year
per $100

$50 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

SBIO$0.50

Expense ratio · Health care peers · Nov 5, 2026

Inside SBIO

103 holdings · as of Nov 5, 2026

SBIO

ALPS Medical Breakthroughs ETF

Today

Biotechnology93.1%ORKA4.4%CGON3.9%MANE3.7%TVTX3.2%DNTH3.1%DFTX2.9%EWTX2.7%RLAY2.6%XENE2.5%ACAD2.4%AMLX2.4%DYNDNLIVRDN56 more holdings52.6% of the fundMGTX OLMAAGMB14 more

Biotechnology93.1%ORKA4.4%CGON3.9%MANE3.7%TVTX3.2%DNTH64 more holdings71.8% of the fundMGTX

#	Ticker	Company	Weight ▼
1	ORKA	Oruka Therapeutics	4.39%
2	CGON	CG oncology	3.92%
3	MANE	VeraDermics	3.73%
4	TVTX	Travere Therapeutics	3.23%
5	DNTH	Dianthus Therapeutics	3.14%
6	DFTX	Definium Therapeutics	2.87%
7	EWTX	Edgewise Therapeutics	2.66%
8	RLAY	Relay Therapeutics	2.59%
9	XENE	Xenon Pharmaceuticals	2.48%
10	ACAD	ACADIA Pharmaceuticals	2.42%

BiotechnologyMedical - DiagnosticsMedical - DevicesOther

ALPS SBIO · current holdings by weight · as of Nov 5, 2026 · each tile is one holding · top 20 = 51.6%

How It Compares

SBIO

ALPS Medical Breakthroughs ETF’s Peers

Today


XLV	SPDRRead Desk	0.08%	−2.5%	+29.6%	$49.1B
VHT	VanguardRead Desk	0.09%	−2.9%	+28.0%	$19.1B
XBI	SPDRRead Desk	0.35%	−6.7%	+37.9%	$10.6B
IYH	iSharesRead Desk	0.37%	−2.8%	+28.8%	$4.9B
IXJ	iSharesRead Desk	0.38%	+3.2%	+28.6%	$4.7B
SBIO	ALPSThis fundRead Desk	0.50%	−5.3%	+21.0%	$187M

Health care peers · Today’s and past-year returns · as of Nov 6, 2026 · sorted by AUM

Head to Head

Put SBIO head to head with XLV →

XLV vs SBIO

YTD

XLVSPDR · Health careSBIOALPS · Health care

Year to date

+20.9%

+3.1%

XLV wins+17.8 pts

Past year

+29.6%

+21.0%

XLV wins+8.5 pts

Fee

0.08%

0.50%

XLV winslower fee

Yield

1.4%

0.0%

XLV wins+1.4 pts

AUM

$49.1B

$187M

XLV262.8× more

4–0XLV wins

SPDR XLV and ALPS SBIO · year-to-date · as of Nov 6, 2026 · AUM not scored

SBIO vs VOO

YTD

SBIO · ALPS Medical Breakthroughs

+3.1%

VOO · S&P 500

+8.4%

Gap

5.3 pts

ALPS SBIO and Vanguard VOO · Today total return · as of Nov 6, 2026

SBIO vs Its Peer Average

YTD

SBIOAvsBPeer average

1D−5.3%−3.4%

1M−2.4%+4.6%

3M−21.9%+3.5%

YTD+3.1%+19.7%

1Y+21.0%+29.0%

3Y+123.3%+75.3%

5Y+18.2%+27.3%

1–6Peer average wins

38 Health care peers · each row scaled to its leader

The Details

SBIO

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y32.86%

Deepest drop · 1Y−29.2%

Lowest point · 5Y−48.0%

52-week range

$52.83

$43.10−25.4% from the high$70.85

ALPS SBIO · past-year price moves · as of Nov 6, 2026

SBIO

Fund Facts

Today

2014launched Dec 30

Tracks[…]

Exchange · CUSIPAMEX · 00162Q593

StructureETF

Leverage1x

Cost on $10,000$50 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

ALPS SBIO · fund facts · as of Nov 6, 2026

SBIO

Payouts by Year

$1.17per share, Dec 2024

Distribution yield0.0%

PaidOnce a year, in December

Latest ex-date · paidDec 19 · Dec 26, 2024

5 payouts added up$2.62 a share

ALPS SBIO · distributions by ex-date · 2017–2024

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

Trading & Liquidity

Net asset value$55.81

Premium / discount[…]

Median spread · 30D[…]

Volume today20K

Average volume · 30D34K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.50%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$50.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Dec 19, 2024	Dec 26, 2024	$1.17
Dec 21, 2023	Dec 27, 2023	$0.0711
Dec 19, 2019	Dec 27, 2019	$0.0158
Dec 20, 2018	Dec 27, 2018	$0.78
Dec 21, 2017	Dec 28, 2017	$0.58

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