ALPS Medical Breakthroughs ETFSBIO

ALPSSectorsHealth Care#171 of 264 by YTD

$54.37

+1.7% last session

+6.1% YTD

Data as of 11/3/20264:00 PM ET · End-of-day

Dividend-adjusted total return · S&P 500 uses VOO · Dec 31, 2025 – Nov 3, 2026SBIOS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	+1.7%	−3.4%	−18.0%	+6.1%	+20.4%	+140.0%	+22.4%	+137.7%
Peer average	+0.6%	+4.0%	+6.1%	+21.0%	+29.0%	+81.2%	+28.9%	—
S&P 500 · VOO	+0.3%	−2.6%	−1.7%	+11.5%	+11.9%	+90.9%	+77.5%	—

Key Statistics

Open all fund facts →

AUM: $182M
Expense ratio: 0.50%
Distribution yield: 0.0%
NAV: $54.40
Volume: 12K
Avg. volume 30D: 39K
High today: $55.05
Low today: $53.66
Previous close: $53.45
52-week high: $70.85
52-week low: $43.10
Our risk indicator: 4/5

SBIO in One Breath

SBIO Among Health Care ETFs

YTD

#1ARKGARK+70.9%$2.2B

#2IDNAiShares+62.8%$340M

#3BBHVanEck+35.0%$525M

#4FTXHFirst Trust+33.8%$1.2B

#5XHSSPDR+32.9%$229M

#6BBPVirtus+29.5%$132M

#7XBISPDR+27.2%$10.5B

#8IHEiShares+26.9%$1.6B

#29SBIOALPS+6.1%$182M

End-of-day Nov 4, 2026 · 33 Health care ETFs by YTD

$10,000 in SBIO

$10,000 in SBIO became

$12,243

In the S&P 500 (VOO)

$17,749

Total return, dividends in · Oct 26, 2021 – Nov 3, 2026 · S&P 500 uses VOO

SBIO’s Top Holdings

Today

ORKAOruka Therapeutics4.3%CGON3.8%MANE3.7%TVTX3.2%DNTH3.2%DFTX3.0%EWTX2.8%RLAY2.6%XENE2.5%ACAD2.4%AMLX2.4%DYN2.2%TARS2.2%IDYA2.1%IRON2.1%DNLI2.1%VRDN2.0%MBX1.8%ZLAB1.7%NAMS1.6%CLDX1.6%81 more

ORKA4.3%CGON3.8%MANE3.7%TVTX3.2%DNTH3.2%DFTX3.0%EWTX2.8%RLAY2.6%XENE2.5%ACAD2.4%AMLX2.4%91 more

Biotechnology

ALPS SBIO · 103 holdings · tile size = share of the fund · as of Nov 3, 2026

What SBIO Holds

Today

Biotechnology93.0%

ORKA 4.3 · CGON 3.8 · MANE 3.7 · TVTX 3.2 · DNTH 3.2 · DFTX 3.0 · EWTX 2.8

Medical - Diagnostics & Research0.4%

FLGT

Medical - Devices0.3%

DCTH

Other holdings6.3%

MGTX · AVBP · SLDB · DSGN · CADL · OLMA · CCCC

ALPS SBIO · share of the fund by industry · as of Nov 3, 2026

Oruka’s Share of SBIO

Today

4.3%

$43 of every $1,000 in SBIO is Oruka

Oruka held by SBIO

$7.9M

Most Oruka per dollar

SBIO4.3%

DWAS1.5%

KBFR0.3%

ALPS SBIO · each square = $10 of $1,000 · as of Nov 3, 2026

SBIO’s Share of Health Care ETFs

Today

0.2%

of the $109B in 39 Health care ETFs

SBIO$182M0.2%

XLV$49.1B45.0%

VHT$19.1B17.5%

36 others$40.7B37.3%

Health care ETF AUM · Nov 4, 2026

SBIO Fee per $100 vs Peers

Today

$0.50a year
per $100

$50 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

SBIO$0.50

Expense ratio · Health care peers · Nov 4, 2026

Inside SBIO

103 holdings · as of Nov 3, 2026

SBIO

ALPS Medical Breakthroughs ETF

Today

Biotechnology93.0%ORKA4.3%CGON3.8%MANE3.7%TVTX3.2%DNTH3.2%DFTX3.0%EWTX2.8%RLAY2.6%XENE2.5%ACAD2.4%AMLX2.4%DYNTARSIDYA56 more holdings52.6% of the fundMGTX AVBPOLMAALT14 more

Biotechnology93.0%ORKA4.3%CGON3.8%MANE3.7%TVTX3.2%DNTH3.2%64 more holdings71.9% of the fundMGTX

#	Ticker	Company	Weight ▼
1	ORKA	Oruka Therapeutics	4.33%
2	CGON	CG oncology	3.76%
3	MANE	VeraDermics	3.71%
4	TVTX	Travere Therapeutics	3.18%
5	DNTH	Dianthus Therapeutics	3.15%
6	DFTX	Definium Therapeutics	2.99%
7	EWTX	Edgewise Therapeutics	2.84%
8	RLAY	Relay Therapeutics	2.60%
9	XENE	Xenon Pharmaceuticals	2.50%
10	ACAD	ACADIA Pharmaceuticals	2.42%

BiotechnologyMedical - DiagnosticsMedical - DevicesOther

ALPS SBIO · current holdings by weight · as of Nov 3, 2026 · each tile is one holding · top 20 = 51.6%

How It Compares

SBIO

ALPS Medical Breakthroughs ETF’s Peers

YTD


XLV	SPDRRead Desk	0.08%	+20.4%	+29.7%	$49.1B
VHT	VanguardRead Desk	0.09%	+19.6%	+28.1%	$19.1B
XBI	SPDRRead Desk	0.35%	+27.2%	+38.1%	$10.5B
IYH	iSharesRead Desk	0.37%	+19.8%	+28.6%	$4.7B
IXJ	iSharesRead Desk	0.38%	+16.0%	+24.7%	$4.6B
SBIO	ALPSThis fundRead Desk	0.50%	+6.1%	+20.4%	$182M

Health care peers · YTD and past-year returns · as of Nov 4, 2026 · sorted by AUM

Head to Head

Put SBIO head to head with XLV →

XLV vs SBIO

YTD

XLVSPDR · Health careSBIOALPS · Health care

Year to date

+20.4%

+6.1%

XLV wins+14.2 pts

Past year

+29.7%

+20.4%

XLV wins+9.3 pts

Fee

0.08%

0.50%

XLV winslower fee

Yield

1.4%

0.0%

XLV wins+1.4 pts

AUM

$49.1B

$182M

XLV269.5× more

4–0XLV wins

SPDR XLV and ALPS SBIO · year-to-date · as of Nov 4, 2026 · AUM not scored

SBIO vs VOO

YTD

SBIO · ALPS Medical Breakthroughs

+6.1%

VOO · S&P 500

+11.5%

Gap

5.4 pts

ALPS SBIO and Vanguard VOO · YTD total return · as of Nov 4, 2026

SBIO vs Its Peer Average

YTD

SBIOAvsBPeer average

1D+1.7%+0.6%

1M−3.4%+4.0%

3M−18.0%+6.1%

YTD+6.1%+21.0%

1Y+20.4%+29.0%

3Y+140.0%+81.2%

5Y+22.4%+28.9%

2–5Peer average wins

38 Health care peers · each row scaled to its leader

The Details

SBIO

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y32.41%

Deepest drop · 1Y−29.2%

Lowest point · 5Y−49.0%

52-week range

$54.37

$43.10−23.3% from the high$70.85

ALPS SBIO · past-year price moves · as of Nov 4, 2026

SBIO

Fund Facts

Today

2014launched Dec 30

Tracks[…]

Exchange · CUSIPAMEX · 00162Q593

StructureETF

Leverage1x

Cost on $10,000$50 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

ALPS SBIO · fund facts · as of Nov 4, 2026

SBIO

Payouts by Year

$1.17per share, Dec 2024

Distribution yield0.0%

PaidOnce a year, in December

Latest ex-date · paidDec 19 · Dec 26, 2024

5 payouts added up$2.62 a share

ALPS SBIO · distributions by ex-date · 2017–2024

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

Trading & Liquidity

Net asset value$54.40

Premium / discount[…]

Median spread · 30D[…]

Volume today12K

Average volume · 30D39K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.50%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$50.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Dec 19, 2024	Dec 26, 2024	$1.17
Dec 21, 2023	Dec 27, 2023	$0.0711
Dec 19, 2019	Dec 27, 2019	$0.0158
Dec 20, 2018	Dec 27, 2018	$0.78
Dec 21, 2017	Dec 28, 2017	$0.58

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