ALPS Medical Breakthroughs ETFSBIO

ALPSSectorsHealth Care#146 of 264 by YTD

$55.78

+5.6% last session

+8.9% YTD

Data as of 11/6/20264:00 PM ET · End-of-day

Dividend-adjusted return from the previous close · S&P 500 uses VOOSBIOS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	+5.6%	+3.4%	−16.9%	+8.9%	+27.5%	+133.3%	+25.7%	+143.9%
Peer average	+0.8%	+5.8%	+2.9%	+20.5%	+29.5%	+75.3%	+27.5%	—
S&P 500 · VOO	+0.3%	−5.0%	−4.6%	+8.7%	+9.8%	+80.8%	+71.8%	—

Key Statistics

Open all fund facts →

AUM: $177M
Expense ratio: 0.50%
Distribution yield: 0.0%
NAV: $52.81
Volume: 18K
Avg. volume 30D: 34K
High today: $55.92
Low today: $52.92
Previous close: $52.83
52-week high: $70.85
52-week low: $43.10
Our risk indicator: 4/5

SBIO in One Breath

SBIO Among Health Care ETFs

YTD

#1IDNAiShares+62.2%$335M

#2ARKGARK+56.9%$2.2B

#3XHSSPDR+35.4%$243M

#4BBHVanEck+33.9%$519M

#5FTXHFirst Trust+32.4%$1.2B

#6BBPVirtus+28.3%$134M

#7IHEiShares+26.8%$1.6B

#8PSCHInvesco+26.5%$187M

#28SBIOALPS+8.9%$177M

End-of-day Nov 6, 2026 · 33 Health care ETFs by YTD

$10,000 in SBIO

$10,000 in SBIO became

$12,566

In the S&P 500 (VOO)

$17,177

Total return, dividends in · Oct 29, 2021 – Nov 6, 2026 · S&P 500 uses VOO

SBIO’s Top Holdings

Today

ORKAOruka Therapeutics4.4%CGON4.0%MANE3.7%DNTH3.2%TVTX3.2%EWTX2.9%DFTX2.8%RLAY2.6%ACAD2.5%XENE2.5%AMLX2.4%DYN2.2%VRDN2.2%DNLI2.2%IRON2.1%TARS2.1%IDYA2.0%VCEL1.8%ZLAB1.8%XNCR1.8%MBX1.6%81 more

ORKA4.4%CGON4.0%MANE3.7%DNTH3.2%TVTX3.2%EWTX2.9%DFTX2.8%RLAY2.6%ACAD2.5%XENE2.5%AMLX2.4%91 more

Biotechnology

ALPS SBIO · 103 holdings · tile size = share of the fund · as of Nov 6, 2026

What SBIO Holds

Today

Biotechnology93.2%

ORKA 4.4 · CGON 4.0 · MANE 3.7 · DNTH 3.2 · TVTX 3.2 · EWTX 2.9 · DFTX 2.8

Medical - Diagnostics & Research0.4%

FLGT

Medical - Devices0.3%

DCTH

Other holdings6.1%

MGTX · SLDB · CADL · DSGN · AVBP · OLMA · ALT

ALPS SBIO · share of the fund by industry · as of Nov 6, 2026

Oruka’s Share of SBIO

Today

4.4%

$44 of every $1,000 in SBIO is Oruka

Oruka held by SBIO

$7.8M

Most Oruka per dollar

SBIO4.4%

DWAS1.6%

KBFR0.3%

ALPS SBIO · each square = $10 of $1,000 · as of Nov 6, 2026

SBIO’s Share of Health Care ETFs

Today

0.2%

of the $112B in 39 Health care ETFs

SBIO$177M0.2%

XLV$50.9B45.4%

VHT$19.1B17.0%

36 others$41.9B37.4%

Health care ETF AUM · Nov 6, 2026

SBIO Fee per $100 vs Peers

Today

$0.50a year
per $100

$50 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

SBIO$0.50

Expense ratio · Health care peers · Nov 6, 2026

Inside SBIO

103 holdings · as of Nov 6, 2026

SBIO

ALPS Medical Breakthroughs ETF

Today

Biotechnology93.2%ORKA4.4%CGON4.0%MANE3.7%DNTH3.2%TVTX3.2%EWTX2.9%DFTX2.8%RLAY2.6%ACAD2.5%XENE2.5%AMLX2.4%DYNVRDNDNLI56 more holdings52.3% of the fundMGTX OLMAAGMB14 more

Biotechnology93.2%ORKA4.4%CGON4.0%MANE3.7%DNTH3.2%TVTX64 more holdings71.8% of the fundMGTX

#	Ticker	Company	Weight ▼
1	ORKA	Oruka Therapeutics	4.40%
2	CGON	CG oncology	3.97%
3	MANE	VeraDermics	3.72%
4	DNTH	Dianthus Therapeutics	3.21%
5	TVTX	Travere Therapeutics	3.18%
6	EWTX	Edgewise Therapeutics	2.92%
7	DFTX	Definium Therapeutics	2.82%
8	RLAY	Relay Therapeutics	2.58%
9	ACAD	ACADIA Pharmaceuticals	2.53%
10	XENE	Xenon Pharmaceuticals	2.53%

See all 104 holdings ↓

BiotechnologyMedical - DiagnosticsMedical - DevicesOther

ALPS SBIO · current holdings by weight · as of Nov 6, 2026 · each tile is one holding · top 20 = 52.4%

All SBIO Holdings

104 holdings · as of Nov 6, 2026

SBIO

SBIO’s Holdings

Today

#
1	ORKAOruka Therapeutics	Healthcare	4.40%	$439.59	81K	$7.8M
2	CGONCG oncology	Healthcare	3.97%	$396.88	108K	$7.0M
3	MANEVeraDermics	Healthcare	3.72%	$371.85	51K	$6.6M
4	DNTHDianthus Therapeutics	Healthcare	3.21%	$321.24	68K	$5.7M
5	TVTXTravere Therapeutics	Healthcare	3.18%	$318.02	115K	$5.6M
6	EWTXEdgewise Therapeutics	Healthcare	2.92%	$291.68	133K	$5.2M
7	DFTXDefinium Therapeutics	Healthcare	2.82%	$281.81	164K	$5.0M
8	RLAYRelay Therapeutics	Healthcare	2.58%	$257.83	268K	$4.6M
9	ACADACADIA Pharmaceuticals	Healthcare	2.53%	$252.73	210K	$4.5M
10	XENEXenon Pharmaceuticals	Healthcare	2.53%	$252.52	119K	$4.5M
11	AMLXAmylyx Pharmaceuticals	Healthcare	2.40%	$239.96	154K	$4.2M
12	DYNDyne Therapeutics	Healthcare	2.24%	$224.37	229K	$4.0M
13	VRDNViridian Therapeutics	Healthcare	2.24%	$223.83	139K	$4.0M
14	DNLIDenali Therapeutics	Healthcare	2.18%	$218.16	196K	$3.9M
15	IRONDisc Medicine	Healthcare	2.08%	$208.45	47K	$3.7M

ALPS SBIO · every reported holding · per $10,000 = dollars of each holding in a $10,000 stake · as of Nov 6, 2026

How It Compares

SBIO

ALPS Medical Breakthroughs ETF’s Peers

YTD


XLV	SPDRRead Desk	0.08%	+20.9%	+29.0%	$50.9B
VHT	VanguardRead Desk	0.09%	+19.8%	+27.4%	$19.1B
XBI	SPDRRead Desk	0.35%	+25.0%	+40.0%	$10.9B
IYH	iSharesRead Desk	0.37%	+20.0%	+27.9%	$4.7B
IXJ	iSharesRead Desk	0.38%	+17.0%	+25.1%	$4.6B
SBIO	ALPSThis fundRead Desk	0.50%	+8.9%	+27.5%	$177M

Health care peers · YTD and past-year returns · as of Nov 7, 2026 · sorted by AUM

Head to Head

Put SBIO head to head with XLV →

XLV vs SBIO

YTD

XLVSPDR · Health careSBIOALPS · Health care

Year to date

+20.9%

+8.9%

XLV wins+12.0 pts

Past year

+29.0%

+27.5%

XLV wins+1.5 pts

Fee

0.08%

0.50%

XLV winslower fee

Yield

1.4%

0.0%

XLV wins+1.4 pts

AUM

$50.9B

$177M

XLV287.9× more

4–0XLV wins

SPDR XLV and ALPS SBIO · year-to-date · as of Nov 7, 2026 · AUM not scored

SBIO vs VOO

YTD

SBIO · ALPS Medical Breakthroughs

+8.9%

VOO · S&P 500

+8.7%

Gap

0.2 pts

ALPS SBIO and Vanguard VOO · YTD total return · as of Nov 7, 2026

SBIO vs Its Peer Average

YTD

SBIOAvsBPeer average

1D+5.6%+0.8%

1M+3.4%+5.8%

3M−16.9%+2.9%

YTD+8.9%+20.5%

1Y+27.5%+29.5%

3Y+133.3%+75.3%

5Y+25.7%+27.5%

2–5Peer average wins

38 Health care peers · each row scaled to its leader

The Details

SBIO

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y33.30%

Deepest drop · 1Y−29.2%

Lowest point · 5Y−47.9%

52-week range

$55.78

$43.10−21.3% from the high$70.85

ALPS SBIO · past-year price moves · as of Nov 7, 2026

SBIO

Fund Facts

Today

2014launched Dec 30

Tracks[…]

Exchange · CUSIPAMEX · 00162Q593

StructureETF

Leverage1x

Cost on $10,000$50 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

ALPS SBIO · fund facts · as of Nov 7, 2026

SBIO

Payouts by Year

$1.17per share, Dec 2024

Distribution yield0.0%

PaidOnce a year, in December

Latest ex-date · paidDec 19 · Dec 26, 2024

5 payouts added up$2.62 a share

ALPS SBIO · distributions by ex-date · 2017–2024

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

Trading & Liquidity

Net asset value$52.81

Premium / discount[…]

Median spread · 30D[…]

Volume today18K

Average volume · 30D34K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.50%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$50.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Dec 19, 2024	Dec 26, 2024	$1.17
Dec 21, 2023	Dec 27, 2023	$0.0711
Dec 19, 2019	Dec 27, 2019	$0.0158
Dec 20, 2018	Dec 27, 2018	$0.78
Dec 21, 2017	Dec 28, 2017	$0.58

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