ALPS Medical Breakthroughs ETFSBIO

ALPSSectorsHealth Care#173 of 264 by YTD

$55.81

+2.6% last session

+9.0% YTD

Data as of 11/4/20264:00 PM ET · End-of-day

Dividend-adjusted total return · S&P 500 uses VOO · Dec 31, 2014 – Nov 4, 2026SBIOS&P 500 · VOO

Returns	1D	1M	3M	YTD	1Y	3Y	5Y	MAX
Total return	+2.6%	+2.6%	−16.9%	+9.0%	+27.0%	+140.9%	+28.2%	+144.0%
Peer average	+2.7%	+8.5%	+8.9%	+24.4%	+33.4%	+84.3%	+34.0%	—
S&P 500 · VOO	+1.6%	−1.6%	0.0%	+13.4%	+13.5%	+91.7%	+81.2%	—

Key Statistics

Open all fund facts →

AUM: $182M
Expense ratio: 0.50%
Distribution yield: 0.0%
NAV: $54.40
Volume: 20K
Avg. volume 30D: 38K
High today: $55.93
Low today: $53.95
Previous close: $54.37
52-week high: $70.85
52-week low: $43.10
Our risk indicator: 4/5

SBIO in One Breath

SBIO Among Health Care ETFs

YTD

#1ARKGARK+71.5%$2.2B

#2IDNAiShares+69.3%$340M

#3XHSSPDR+40.0%$229M

#4BBHVanEck+38.2%$525M

#5FTXHFirst Trust+36.8%$1.2B

#6PSCHInvesco+31.7%$178M

#7XBISPDR+30.6%$10.5B

#8IHEiShares+29.8%$1.6B

#31SBIOALPS+9.0%$182M

End-of-day Nov 5, 2026 · 33 Health care ETFs by YTD

$10,000 in SBIO

$10,000 in SBIO became

$12,821

In the S&P 500 (VOO)

$18,115

Total return, dividends in · Oct 27, 2021 – Nov 4, 2026 · S&P 500 uses VOO

SBIO’s Top Holdings

Today

ORKAOruka Therapeutics4.4%CGON3.8%MANE3.8%TVTX3.1%DNTH3.1%DFTX3.0%EWTX2.7%RLAY2.6%XENE2.5%AMLX2.5%ACAD2.4%DYN2.3%TARS2.1%IRON2.1%DNLI2.1%IDYA2.0%VRDN1.9%MBX1.8%ZLAB1.7%NAMS1.6%CLDX1.6%81 more

ORKA4.4%CGON3.8%MANE3.8%TVTX3.1%DNTH3.1%DFTX3.0%EWTX2.7%RLAY2.6%XENE2.5%AMLX2.5%ACAD2.4%91 more

Biotechnology

ALPS SBIO · 103 holdings · tile size = share of the fund · as of Nov 4, 2026

What SBIO Holds

Today

Biotechnology93.0%

ORKA 4.4 · CGON 3.8 · MANE 3.8 · TVTX 3.1 · DNTH 3.1 · DFTX 3.0 · EWTX 2.7

Medical - Diagnostics & Research0.4%

FLGT

Medical - Devices0.3%

DCTH

Other holdings6.3%

MGTX · CADL · SLDB · DSGN · OLMA · AVBP · ALT

ALPS SBIO · share of the fund by industry · as of Nov 4, 2026

Oruka’s Share of SBIO

Today

4.4%

$44 of every $1,000 in SBIO is Oruka

Oruka held by SBIO

$8.1M

Most Oruka per dollar

SBIO4.4%

DWAS1.5%

KBFR0.3%

ALPS SBIO · each square = $10 of $1,000 · as of Nov 4, 2026

SBIO’s Share of Health Care ETFs

Today

0.2%

of the $109B in 39 Health care ETFs

SBIO$182M0.2%

XLV$49.1B45.0%

VHT$19.1B17.5%

36 others$40.7B37.3%

Health care ETF AUM · Nov 5, 2026

SBIO Fee per $100 vs Peers

Today

$0.50a year
per $100

$50 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

SBIO$0.50

Expense ratio · Health care peers · Nov 5, 2026

Inside SBIO

103 holdings · as of Nov 4, 2026

SBIO

ALPS Medical Breakthroughs ETF

Today

Biotechnology93.0%ORKA4.4%CGON3.8%MANE3.8%TVTX3.1%DNTH3.1%DFTX3.0%EWTX2.7%RLAY2.6%XENE2.5%AMLX2.5%ACAD2.4%DYNTARSIRON56 more holdings52.6% of the fundMGTX AVBPAGMB14 more

Biotechnology93.0%ORKA4.4%CGON3.8%MANE3.8%TVTXDNTH64 more holdings71.8% of the fundMGTX

#	Ticker	Company	Weight ▼
1	ORKA	Oruka Therapeutics	4.43%
2	CGON	CG oncology	3.82%
3	MANE	VeraDermics	3.75%
4	TVTX	Travere Therapeutics	3.13%
5	DNTH	Dianthus Therapeutics	3.11%
6	DFTX	Definium Therapeutics	3.02%
7	EWTX	Edgewise Therapeutics	2.75%
8	RLAY	Relay Therapeutics	2.57%
9	XENE	Xenon Pharmaceuticals	2.49%
10	AMLX	Amylyx Pharmaceuticals	2.46%

BiotechnologyMedical - DiagnosticsMedical - DevicesOther

ALPS SBIO · current holdings by weight · as of Nov 4, 2026 · each tile is one holding · top 20 = 51.5%

How It Compares

SBIO

ALPS Medical Breakthroughs ETF’s Peers

YTD


XLV	SPDRRead Desk	0.08%	+24.0%	+33.5%	$49.1B
VHT	VanguardRead Desk	0.09%	+23.3%	+32.1%	$19.1B
XBI	SPDRRead Desk	0.35%	+30.6%	+45.4%	$10.5B
IYH	iSharesRead Desk	0.37%	+23.7%	+32.8%	$4.7B
IXJ	iSharesRead Desk	0.38%	+19.7%	+28.6%	$4.6B
SBIO	ALPSThis fundRead Desk	0.50%	+9.0%	+27.0%	$182M

Health care peers · YTD and past-year returns · as of Nov 5, 2026 · sorted by AUM

Head to Head

Put SBIO head to head with XLV →

XLV vs SBIO

YTD

XLVSPDR · Health careSBIOALPS · Health care

Year to date

+24.0%

+9.0%

XLV wins+15.1 pts

Past year

+33.5%

+27.0%

XLV wins+6.5 pts

Fee

0.08%

0.50%

XLV winslower fee

Yield

1.3%

0.0%

XLV wins+1.3 pts

AUM

$49.1B

$182M

XLV269.5× more

4–0XLV wins

SPDR XLV and ALPS SBIO · year-to-date · as of Nov 5, 2026 · AUM not scored

SBIO vs VOO

YTD

SBIO · ALPS Medical Breakthroughs

+9.0%

VOO · S&P 500

+13.4%

Gap

4.4 pts

ALPS SBIO and Vanguard VOO · YTD total return · as of Nov 5, 2026

SBIO vs Its Peer Average

YTD

SBIOAvsBPeer average

1D+2.6%+2.7%

1M+2.6%+8.5%

3M−16.9%+8.9%

YTD+9.0%+24.4%

1Y+27.0%+33.4%

3Y+140.9%+84.3%

5Y+28.2%+34.0%

1–6Peer average wins

38 Health care peers · each row scaled to its leader

The Details

SBIO

Risk

4/5our risk indicator

CalmerBumpier

Volatility · 1Y32.39%

Deepest drop · 1Y−29.2%

Lowest point · 5Y−46.8%

52-week range

$55.81

$43.10−21.2% from the high$70.85

ALPS SBIO · past-year price moves · as of Nov 5, 2026

SBIO

Fund Facts

Today

2014launched Dec 30

Tracks[…]

Exchange · CUSIPAMEX · 00162Q593

StructureETF

Leverage1x

Cost on $10,000$50 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

ALPS SBIO · fund facts · as of Nov 5, 2026

SBIO

Payouts by Year

$1.17per share, Dec 2024

Distribution yield0.0%

PaidOnce a year, in December

Latest ex-date · paidDec 19 · Dec 26, 2024

5 payouts added up$2.62 a share

ALPS SBIO · distributions by ex-date · 2017–2024

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

Trading & Liquidity

Net asset value$54.40

Premium / discount[…]

Median spread · 30D[…]

Volume today20K

Average volume · 30D38K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.50%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$50.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Dec 19, 2024	Dec 26, 2024	$1.17
Dec 21, 2023	Dec 27, 2023	$0.0711
Dec 19, 2019	Dec 27, 2019	$0.0158
Dec 20, 2018	Dec 27, 2018	$0.78
Dec 21, 2017	Dec 28, 2017	$0.58

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