ALPSSectorsHealth Care#134 of 264 by YTD

ALPS Medical Breakthroughs ETFSBIO

S&P 500 Compare

$57.60+3.3%

+$1.82 · Nov 9 close

Buy

AUM: $193M
Fee: 0.50%
Yield: 0.0%

Bumpy · 1Y: 2.4×S&P
Volume: 22K
NAV: $57.55

What's insideAll 104 →

ORKA 4.5%CGON 4.4%MANE 3.8%EWTX 3.2%

52-week range19% below the high

$43.10$70.85

Returns	Today	1W	1M	3M	YTD	1Y	3Y	5Y	Max
Total return	+3.3%	+7.8%	+4.7%	−14.2%	+12.5%	+30.1%	+138.3%	+25.8%	+151.9%
Peer average	+2.4%	+2.8%	+6.4%	+5.5%	+23.4%	+33.1%	+76.7%	+28.9%	—
S&P 500 · VOO	+2.3%	+0.1%	−3.3%	−2.1%	+11.3%	+13.6%	+81.6%	+75.4%	—

SBIO in One Breath

SBIO Among Health Care ETFs

YTD

#1IDNAiShares+67.1%$363M

#2ARKGARK+66.6%$2.2B

#3XHSSPDR+37.5%$241M

#4BBHVanEck+37.1%$524M

#5FTXHFirst Trust+35.3%$1.2B

#6BBPVirtus+30.8%$133M

#7PSCHInvesco+29.7%$181M

#8XBISPDR+28.8%$10.3B

#28SBIOALPS+12.5%$193M

End-of-day Nov 10, 2026 · 33 Health care ETFs by YTD

$10,000 in SBIO

$10,000 in SBIO became

$12,582

In the S&P 500 (VOO)

$17,543

Total return, dividends in · Nov 1, 2021 – Nov 9, 2026 · S&P 500 uses VOO

SBIO’s Top Holdings

Today

ORKAOruka Therapeutics4.5%CGON4.4%MANE3.8%EWTX3.2%DNTH3.2%TVTX3.1%DFTX2.9%RLAY2.7%XENE2.5%AMLX2.4%ACAD2.4%DYN2.2%VRDN2.1%DNLI2.1%IRON2.0%IDYA2.0%TARS2.0%ZLAB1.9%VCEL1.8%XNCR1.7%PVLA1.7%81 more

ORKA4.5%CGON4.4%MANE3.8%EWTX3.2%DNTH3.2%TVTX3.1%DFTX2.9%RLAY2.7%XENE2.5%AMLX2.4%ACAD2.4%91 more

Biotechnology

ALPS SBIO · 103 holdings · tile size = share of the fund · as of Nov 9, 2026

What SBIO Holds

Today

Biotechnology93.1%

ORKA 4.5 · CGON 4.4 · MANE 3.8 · EWTX 3.2 · DNTH 3.2 · TVTX 3.1 · DFTX 2.9

Medical - Diagnostics & Research0.4%

FLGT

Medical - Devices0.3%

DCTH

Other holdings6.1%

MGTX · SLDB · AVBP · CADL · OLMA · DSGN · TECX

ALPS SBIO · share of the fund by industry · as of Nov 9, 2026

Oruka’s Share of SBIO

Today

4.5%

$45 of every $1,000 in SBIO is Oruka

Oruka held by SBIO

$8.6M

Most Oruka per dollar

SBIO4.5%

XBI1.7%

DWAS1.6%

KBFR0.3%

ALPS SBIO · each square = $10 of $1,000 · as of Nov 9, 2026

SBIO’s Share of Health Care ETFs

Today

0.2%

of the $110B in 39 Health care ETFs

SBIO$193M0.2%

XLV$49.7B45.0%

VHT$19.1B17.3%

36 others$41.5B37.5%

Health care ETF AUM · Nov 10, 2026

SBIO Fee per $100 vs Peers

Today

$0.50a year
per $100

$50 a year on $10,000

XLV$0.08

VHT$0.09

XBI$0.35

IYH$0.37

IXJ$0.38

SBIO$0.50

Expense ratio · Health care peers · Nov 10, 2026

Inside SBIO

103 holdings · as of Nov 9, 2026

SBIO

ALPS Medical Breakthroughs ETF

Today

Biotechnology93.1%ORKA4.5%CGON4.4%MANE3.8%EWTX3.2%DNTH3.2%TVTX3.1%DFTX2.9%RLAY2.7%XENE2.5%AMLX2.4%ACAD2.4%DYNVRDNDNLI56 more holdings51.7% of the fundFLGTMGTX DSGNRZLT14 more

Biotechnology93.1%ORKA4.5%CGON4.4%MANE3.8%EWTXDNTH64 more holdings71.1% of the fundMGTX

#	Ticker	Company	Weight ▼
1	ORKA	Oruka Therapeutics	4.46%
2	CGON	CG oncology	4.40%
3	MANE	VeraDermics	3.80%
4	EWTX	Edgewise Therapeutics	3.20%
5	DNTH	Dianthus Therapeutics	3.15%
6	TVTX	Travere Therapeutics	3.05%
7	DFTX	Definium Therapeutics	2.92%
8	RLAY	Relay Therapeutics	2.67%
9	XENE	Xenon Pharmaceuticals	2.48%
10	AMLX	Amylyx Pharmaceuticals	2.43%

See all 104 holdings ↓

BiotechnologyMedical - DiagnosticsMedical - DevicesOther

ALPS SBIO · current holdings by weight · as of Nov 9, 2026 · each tile is one holding · top 20 = 52.8%

All SBIO Holdings

104 holdings · as of Nov 9, 2026

SBIO

SBIO’s Holdings

Today

#
1	ORKAOruka Therapeutics	Healthcare	4.46%	$445.67	81K	$8.3M
2	CGONCG oncology	Healthcare	4.40%	$440.47	108K	$8.2M
3	MANEVeraDermics	Healthcare	3.80%	$379.79	51K	$7.1M
4	EWTXEdgewise Therapeutics	Healthcare	3.20%	$319.87	133K	$6.0M
5	DNTHDianthus Therapeutics	Healthcare	3.15%	$315.08	68K	$5.9M
6	TVTXTravere Therapeutics	Healthcare	3.05%	$305.47	115K	$5.7M
7	DFTXDefinium Therapeutics	Healthcare	2.92%	$292.27	164K	$5.5M
8	RLAYRelay Therapeutics	Healthcare	2.67%	$266.98	268K	$5.0M
9	XENEXenon Pharmaceuticals	Healthcare	2.48%	$248.44	119K	$4.6M
10	AMLXAmylyx Pharmaceuticals	Healthcare	2.43%	$242.56	154K	$4.5M
11	ACADACADIA Pharmaceuticals	Healthcare	2.39%	$239.07	210K	$4.5M
12	DYNDyne Therapeutics	Healthcare	2.21%	$221.03	229K	$4.1M
13	VRDNViridian Therapeutics	Healthcare	2.11%	$211.39	139K	$4.0M
14	DNLIDenali Therapeutics	Healthcare	2.10%	$210.14	196K	$3.9M
15	IRONDisc Medicine	Healthcare	1.98%	$198.39	47K	$3.7M

ALPS SBIO · every reported holding · per $10,000 = dollars of each holding in a $10,000 stake · as of Nov 9, 2026

How It Compares

SBIO

ALPS Medical Breakthroughs ETF’s Peers

YTD


XLV	SPDRRead Desk	0.08%	+23.2%	+31.2%	$49.7B
VHT	VanguardRead Desk	0.09%	+22.2%	+29.9%	$19.1B
XBI	SPDRRead Desk	0.35%	+28.8%	+44.2%	$10.3B
IYH	iSharesRead Desk	0.37%	+22.4%	+30.4%	$4.8B
IXJ	iSharesRead Desk	0.38%	+19.1%	+27.0%	$4.7B
SBIO	ALPSThis fundRead Desk	0.50%	+12.5%	+30.1%	$193M

Health care peers · YTD and past-year returns · as of Nov 10, 2026 · sorted by AUM

Head to Head

Put SBIO head to head with XLV →

XLV vs SBIO

YTD

XLVSPDR · Health careSBIOALPS · Health care

Year to date

+23.2%

+12.5%

XLV wins+10.7 pts

Past year

+31.2%

+30.1%

XLV wins+1.1 pts

Fee

0.08%

0.50%

XLV winslower fee

Yield

1.4%

0.0%

XLV wins+1.4 pts

AUM

$49.7B

$193M

XLV257.7× more

4–0XLV wins

SPDR XLV and ALPS SBIO · year-to-date · as of Nov 10, 2026 · AUM not scored

SBIO vs VOO

YTD

SBIO · ALPS Medical Breakthroughs

+12.5%

VOO · S&P 500

+11.3%

Gap

1.2 pts

ALPS SBIO and Vanguard VOO · YTD total return · as of Nov 10, 2026

SBIO vs Its Peer Average

YTD

SBIOAvsBPeer average

1D+3.3%+2.4%

1M+4.7%+6.4%

3M−14.2%+5.5%

YTD+12.5%+23.4%

1Y+30.1%+33.1%

3Y+138.3%+76.7%

5Y+25.8%+28.9%

2–5Peer average wins

38 Health care peers · each row scaled to its leader

How Bumpy Is SBIO?

View

SBIO

How Bumpy

2.4×the S&P 500’s swings

CalmerBumpierS&P 1×SBIO

Bumpiest of 7 health care fundsSBIO

Other health care funds1.2× to 2.2×

ALPS SBIO · daily swings over the past year vs the S&P 500

SBIO

Worst Drop

−29.2%from its Aug 19 high

Still below the high−18.6%

$10,000 at the high is now$8,140

ALPS SBIO · fall from the highest close, past year

SBIO

On a Bad Day

1.0×the S&P 500’s fall

SBIO’s worst day: Wednesday, Sep 23

SBIO

−5.5%

S&P 500

−0.7%

Up days53 of every 100

S&P 500 up days52 of every 100

ALPS SBIO · average move on days the S&P 500 fell

SBIO

Return for the Bumps

1Y#6 of 7 health care funds

#1XLVSPDR

most for the bumps

#2VHTVanguard

#3IYHiShares

#4IXJiShares

calmest ride

#5XBISPDR

#6SBIOALPS

#7IHIiShares

lost money

Ranked by return above cash for each unit of bumpiness (Sharpe ratio) · cash = 3.8%

SBIO

Cost

Today

$50a year per $10,000

XLV

VHT

XBI

$35

IYH

$37

IHI

$37

IXJ

$38

SBIO

$50

Expense ratio 0.50%, taken from the fund’s value

SBIO

Volatility & Beta

33.4%annual volatility

S&P 500 volatility13.7%

Downside volatility22.0%

Beta vs SPY1.11

Correlation vs SPY0.45

Beta rank, lowest first, of 7#6

Daily total returns × √252 · past 254 trading days

SBIO

Max Drawdown

−29.2%peak to trough

Peak closeAug 19, 2026

Current drawdown−18.6%

Worst day−5.52% · Sep 23

Closing prices, dividends in

SBIO

Up / Down Capture

96%down capture vs SPY

Down days

96%

Up days

120%

S&P 500

100%

Up ÷ down capture1.25

Up days52.8% (S&P 52.4%)

Average daily move on SPY up days and down days

SBIO

Sharpe & Sortino vs Peers

Fund	Sharpe	Sortino	Volatility	Max DD	Beta	Fee / $10k
XLV	1.66	2.85	16.9%	−10.5%	0.31	$8
VHT	1.63	2.77	16.4%	−10.4%	0.39	$9
IYH	1.61	2.73	17.0%	−10.6%	0.36	$37
IXJ	1.46	2.46	16.4%	−10.8%	0.36	$38
XBI	1.40	2.12	30.1%	−14.9%	1.15	$35
SBIO	0.84	1.28	33.4%	−29.2%	1.11	$50
IHI	−0.33	−0.50	22.1%	−26.1%	0.47	$37

Sharpe = (return − 3.8% cash) ÷ volatility · Sortino uses downside volatility only

SBIO

Trading

Today

+0.09%above its holdings’ value

Close$57.60

NAV$57.55

Fee per $10,000$50 a year

Avg. volume 30D33K shares

Premium / discount history starts once daily NAV is saved

Close vs net asset value, Nov 9

The Details

SBIO

Fund Facts

Today

2014launched Dec 30

Tracks[…]

Exchange · CUSIPAMEX · 00162Q593

StructureETF

Leverage1x

Cost on $10,000$50 a year

Go deeper

Prospectus & documents Trading & liquidity Fees & costs Distributions

ALPS SBIO · fund facts · as of Nov 10, 2026

SBIO

Payouts by Year

$1.17per share, Dec 2024

Distribution yield0.0%

PaidOnce a year, in December

Latest ex-date · paidDec 19 · Dec 26, 2024

5 payouts added up$2.62 a share

ALPS SBIO · distributions by ex-date · 2017–2024

All Fund FactsDocuments · trading · fees · every payout

Prospectus & Documents

Trading & Liquidity

Net asset value$57.55

Premium / discount[…]

Median spread · 30D[…]

Volume today22K

Average volume · 30D33K

Shares outstanding[…]

Options[…]

Fees & Costs

Net expense ratio0.50%

Gross expense ratio[…]

Management fee[…]

Cost on $10,000 a year$50.00

Our risk indicator4/5

Estimated yearly cost excludes trading costs and assumes constant assets.

Distributions

Ex-date	Paid	Per share
Dec 19, 2024	Dec 26, 2024	$1.17
Dec 21, 2023	Dec 27, 2023	$0.0711
Dec 19, 2019	Dec 27, 2019	$0.0160
Dec 20, 2018	Dec 27, 2018	$0.78
Dec 21, 2017	Dec 28, 2017	$0.58

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